Evidence map›Paper›PMID 34339085›Full record

ArticleJournal of thrombosis and haemostasis : JTH2021

Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study.

Wobke E M van Dijk, Jelle S Nijdam, Saskia Haitjema, Mark C H de Groot, Albert Huisman, Marieke C Punt, Annemiek C C Evers, Roger E G Schutgens, A Titia Lely, Karin P M van Galen

Open access · hybridAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. A practical approach to immune thrombocytopenia in pregnancy.Hematology. American Society of Hematology. Education Program · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Special Issue "Advances in Thrombocytopenia".Journal of clinical medicine · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wobke E M van DijkBenign Hematology, Van Creveldkliniek, University Medical Center, Utrecht, The Netherlands.ORCID 0000-0002-0821-7875
Jelle S NijdamUniversity Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-9925-5921
Saskia HaitjemaClinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-5465-4868
Mark C H de GrootClinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-5764-5788
Albert HuismanClinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0002-2291-2487
Marieke C PuntBenign Hematology, Van Creveldkliniek, University Medical Center, Utrecht, The Netherlands.ORCID 0000-0002-1891-5255
Annemiek C C EversObstetrics and Gynecology, University Medical Center Utrecht, Utrecht, Netherlands.
Roger E G SchutgensBenign Hematology, Van Creveldkliniek, University Medical Center, Utrecht, The Netherlands.ORCID 0000-0002-2762-6033
A Titia LelyObstetrics and Gynecology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID 0000-0001-6356-7707
Karin P M van GalenBenign Hematology, Van Creveldkliniek, University Medical Center, Utrecht, The Netherlands.ORCID 0000-0003-3251-8595
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere postpartum hemorrhage (SPPH) is the leading cause of maternal mortality and morbidity worldwide. Platelet anomalies frequently occur during pregnancy. However, their role in the etiology of SPPH is largely unknown.

objectiveTo study the relation between platelet parameters and SPPH.

methodsThis retrospective single-center cohort included deliveries between 2009 and 2017. SPPH was defined as ≥1000 ml blood loss within 24 h after delivery. Platelet parameters were measured within 72 h before delivery. Multiple imputation was performed for missing data. Odds ratios were adjusted (aORs) for maternal age, multiple gestation, macrosomia, induction of labor, preeclampsia, and hemolysis, elevated liver enzymes, and low platelets syndrome.

resultsA total of 23 205 deliveries were included. Of the 2402 (10.4%) women with thrombocytopenia (<150 × 10

conclusionDifferent degrees of thrombocytopenia were independently associated with the occurrence of SPPH. Despite their relation to SPPH, plateletcrit and a PDW of ≥23% have limited additional value in addition to platelet count.

Indexed as

Postpartum HemorrhageCohort StudiesFemaleHumansMaternal AgePlatelet CountPregnancyRetrospective StudiesRisk Factorsmean platelet volumeplatelet countpostpartum hemorrhagepregnancy complicationsthrombocytopenia

Identifiers

PMID34339085
PMCPMC9292153
OpenAlexW3190527035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.