Evidence map›Paper›PMID 34338997›Full record

ArticleBrain imaging and behavior2022

Associations between gait speed and brain structure in amnestic mild cognitive impairment: a quantitative neuroimaging study.

Pauline Ali, Matthieu Labriffe, Paul Paisant, Marc Antoine Custaud, Cédric Annweiler, Mickaël Dinomais

Abstract read
PubMed Publisher
In one paragraph

Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pauline AliLaboratoire Angevin de Recherche en Ingénierie Des Systèmes, EA7315, University of Angers, Angers, France. Pauline.ali@univ-angers.fr.ORCID http://orcid.org/0000-0002-7652-2548
Matthieu LabriffeLaboratoire Angevin de Recherche en Ingénierie Des Systèmes, EA7315, University of Angers, Angers, France.
Paul PaisantLes Capucins, Centre de Réadaptation Spécialisée et Soins Longue Durée, 11 Boulevard Jean Sauvage, F-49100, Angers, France.
Marc Antoine CustaudCRC, Clinical Research Center, Angers University Hospital, Angers, France.
Cédric AnnweilerDepartment of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, Angers, France.
Mickaël DinomaisLaboratoire Angevin de Recherche en Ingénierie Des Systèmes, EA7315, University of Angers, Angers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with amnestic mild cognitive impairment (aMCI) present gait disturbances including slower speed and higher variability when compared to cognitively healthy individuals (CHI). Brain neuroimaging could explore higher levels of motor control. Our purpose was to look for an association between morphometrics and gait parameters in each group. We hypothesized that the relation between morphological cerebral alteration and gait speed are different following the group.

methodsFifty-three participants (30 with aMCI and 23 CHI) were recruited in this French cross-sectional study (mean 72 ± 5 years, 38% female). Gait speed and gait variability (coefficients of variation of stride time (STV) and stride length (SLV)) were measured using GAITrite® system. CAT12 software was used to analyse volume and surface morphometry like gray matter volume (GMV) and cortical thickness (CT). Age, gender and education level were used as potential cofounders.

resultsaMCI had slower gait speed and higher STV when compared to CHI. In aMCI the full adjusted linear regression model showed that lower gait speed was associated with decreased GMV and lower CT in bilateral superior temporal gyri (p < 0.36). In CHI, no association was found between gait speed and brain structure. Higher SLV was correlated with reduced GMV in spread regions (p < 0.05) and thinner cortex in the middle right frontal gyrus (p = 0.001) in aMCI. In CHI, higher SLV was associated with reduced GMV in 1 cluster: the left lingual (p = 0.041).

conclusionsThese findings indicate that lower gait speed is associated with specific brain structural changes as reduced GMV and CT during aMCI.

Indexed as

Cognitive DysfunctionWalking SpeedBrainCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingBrain imagingGait disordersMild cognitive impairmentStatistical parametric mapping

Identifiers

PMID34338997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.