Evidence map›Paper›PMID 34338929›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Correlation of serotype-specific strain in patients with dengue virus infection with neurological manifestations and its outcome.

Atul Pandey, Rajesh Verma, Amita Jain, Shantanu Prakash, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Sweta Pandey and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Chikungunya and Dengue Encephalitis: A Critical Narrative Review.Annals of Indian Academy of Neurology · 2025
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atul PandeyDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Rajesh VermaDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003. drrajeshverma32@yahoo.com.ORCID http://orcid.org/0000-0001-7016-2361
Amita JainDepartment of Microbiology, King George's Medical University, Lucknow, India.
Shantanu PrakashDepartment of Microbiology, King George's Medical University, Lucknow, India.
Ravindra Kumar GargDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Hardeep Singh MalhotraDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Praveen Kumar SharmaDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Neeraj KumarDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Ravi UniyalDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Sweta PandeyDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.
Imran RizviDepartment of Neurology, King George's Medical University, Lucknow, India, PIN-226003.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeurological manifestation of dengue virus infection is a rare entity. Serotypes commonly associated with neurological manifestation are DENV-2 and DENV-3. We plan to detect the serotypes related to the neurological presentation in dengue infection and its correlation with different neurological complications and outcome.

methodsIn this case-control study, consecutive dengue cases with different neurological manifestations were enrolled along with age and sex-matched controls (dengue patients without neurological complication). Serotyping using RT-PCR of samples of cases and controls were done. Level of correlation was analyzed with various parameters and outcomes.

resultsIn cases out of 33 samples, 6 sample serotypes were detected, which were composed of DENV-1 (n = 2) and DENV-2 (n = 4). In controls, DENV-1 (n = 5), DENV-2 (n = 6), and DENV-3 (n = 3) were detected. When statistically correlated, no significant association was found in cases and controls with dengue virus serotype. The frequency of serotype 2 was higher in hypokalemic paralysis cases than non-hypokalemic paralysis cases and the difference was significant (p < 0.05). The outcome was good (mRS < 3) in all the cases where serotypes were detected, but on statistical correlation, it was not found significant (p > 0.05).

conclusionDENV-1 and DENV-2 are associated with neurological manifestation of dengue infection, which is different from the existing literature, where DENV-2 and DENV-3 are reported. The detection of DENV serotype will help in predicting and best management of neurological complication. The serotype 2 of dengue virus is more commonly associated with dengue-associated hypokalemic paralysis than other neurological complication (p < 0.05). There is no significant association of serotypes with outcome or mortality.

Indexed as

DengueDengue VirusCase-Control StudiesHumansSerogroupSerotypingArbovirusDengueHypokalemic paralysisInfectionNeurological manifestationsSerotype

Identifiers

PMID34338929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.