Evidence map›Paper›PMID 34338858›Full record

ArticleJournal of neurology2022

Disentangling the PIGD classification for the prediction of cognitive impairment in de novo Parkinson's disease.

Daniele Urso, Valentina Leta, Lucia Batzu, Tayyabah Yousaf, Chloe Farrell, Daniel J van Wamelen, K Ray Chaudhuri

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Association of the DTI-ALPS index with motor and non-motor symptoms in Parkinson's disease with postural instability/gait difficulty: a diffusion tensor MRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Daniele UrsoDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. daniele.urso@kcl.ac.uk.ORCID http://orcid.org/0000-0002-4503-0110
Valentina LetaDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Lucia BatzuDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tayyabah YousafDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Chloe FarrellDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Daniel J van WamelenDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
K Ray ChaudhuriDepartment of Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
King's College London · GBRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostural Instability and Gait difficulties (PIGD) subtype has been associated with worse cognitive performance in Parkinson's disease (PD).

objectiveTo investigate whether PIGD subtype classification or PIGD-related clinical features predict the development of cognitive decline in de novo PD patients.

methodsData from 422 PD patients with de novo PD were obtained from the PPMI database. At follow-up (up to 6 years), patients were categorized as having cognitive impairment or not. Multivariate Cox survival analysis was carried out including motor subtype and individual MDS-UPDRS items defining PIGD phenotype as predictors. Previously validated clinical predictors of cognitive impairment were included in the model as covariates. Occurrence of cognitive impairment at follow-up was used as the time-to-event and Kaplan-Meier curve was generated.

resultsAt baseline, 76 patients were classified as PIGD, 299 tremor-dominant and 47 as indeterminate. Development of cognitive impairment was not associated with PIGD subtype (p = 0.252). When individual MDS-UPDRS items were interrogated in the model, postural instability proved to be an independent predictor of cognitive impairment (HR = 2.045; 95%CI: 1.068-3.918; p = 0.031), while gait difficulties were not associated with cognitive decline (p = 0.870).

conclusionsOur findings suggest that postural instability, as assessed by MDS-UPDRS III, may serve as a possible indicator of the risk of developing cognitive impairment in de novo PD patients rather than the PIGD phenotype.

Indexed as

Cognitive DysfunctionGait Disorders, NeurologicParkinson DiseaseGaitHumansPostural BalanceTremorCognitive impairmentParkinson’s diseasePIGDPostural instability

Identifiers

PMID34338858
PMCPMC8857169
OpenAlexW3189167529

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.