Evidence map›Paper›PMID 34338749›Full record

ArticleInvestigative ophthalmology & visual science2021

Retinal Responses to Simulated Optical Blur Using a Novel Dead Leaves ERG Stimulus.

Athanasios Panorgias, Stephanie Aigbe, Emily Jeong, Carles Otero, Peter J Bex, Fuensanta A Vera-Diaz

Abstract read
In one paragraph

Article in Investigative ophthalmology & visual science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Sustained Plus Lens Defocus Alters Retinal Responses and Ciliary Muscle Morphology In Myopes and Near-emmetropes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Optical influence of myopia control spectacles at the retinal level: Effect of local light modulation.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Article
  7. Article
  8. Article
  9. Choroidal Control Technology: New Horizons in Maculopathy and Presbyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Baseline metrics that may predict future myopia in young children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Athanasios PanorgiasNew England College of Optometry, Boston, Massachusetts, United States.
Stephanie AigbeNew England College of Optometry, Boston, Massachusetts, United States.
Emily JeongNew England College of Optometry, Boston, Massachusetts, United States.
Carles OteroEMEA Scientific Communications - Alcon, Barcelona, Cataluña, Spain.
Peter J BexNew England College of Optometry, Boston, Massachusetts, United States.
Fuensanta A Vera-DiazNew England College of Optometry, Boston, Massachusetts, United States.

Funding

PICNIC: Intrinsic factorspredictive of childhood myopiaR01EY030518 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI Fuensanta Ascension Vera-Diaz · 2019 to 2026
$2.4M
Eye Movement Rehabilitation in Low Vision PatientsR01EY029713 · NEI · NORTHEASTERN UNIVERSITY · PI BEX, PETER JOHN · 2019 to 2023
$1.9M
SHORT TERM RES TRAINING AT THE NEW ENGLAND COLLEGE OFT35EY007149 · NEI · NEW ENGLAND COLLEGE OF OPTOMETRY · PI Athanasios Panorgias · 1999 to 2026
$1.5M
NEI NIH HHS R01 EY029713NEI NIH HHS R01 EY030518NEI NIH HHS T35 EY007149
6 · The paper itself

Abstract

Purpose: The purpose of this study was to evaluate retinal responses to different types and magnitudes of simulated optical blur presented at specific retinal eccentricities using naturalistic images. Methods: Electroretinograms (ERGs) were recorded from 27 adults using 30-degree dead leaves naturalistic images, digitally blurred with one of three types of optical blur (defocus, astigmatism, and spherical aberrations), and one of three magnitudes (0.1, 0.3, or 0.5 µm) of blur. Digitally computed blur was applied to the entire image, or on an area outside the central 6 degrees or 12 degrees of retinal eccentricity. Results: ERGs were significantly affected by blur type, magnitude, and retinal eccentricity. ERGs were differentially affected by defocus and spherical aberrations; however, astigmatism had no effect on the ERGs. When blur was applied only beyond the central 12 degrees eccentricity, the ERGs were unaffected. However, when blur was applied outside the central 6 degrees, the ERG responses were significantly reduced and were no different from the ERGs recorded with entirely blurred images. Conclusions: Blur type, magnitude, and location all affect the retinal responses. Our data indicate that the retinal area between 6 and 12 degrees eccentricity has the largest effect on the retinal responses to blur. In addition, certain optical blur types appear to have a more detrimental effect on the ERGs than others. These results cannot be solely explained by changes to image contrast and spatial frequency content, suggesting that retinal neurons might be sensitive to spatial cues in order to differentiate between different blur types.

Indexed as

Visual AcuityAdultElectroretinographyFemaleHumansMalePhotic StimulationRefraction, OcularRetinaVision DisordersYoung Adult

Identifiers

PMID34338749
PMCPMC8340654

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.