Evidence map›Paper›PMID 34338643›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2022

Phasic flow patterns of right versus left coronary arteries in patients undergoing clinical physiological assessment.

Henry Seligman, Sukhjinder S Nijjer, Tim P van de Hoef, Guus A de Waard, Hernán Mejía-Rentería, Mauro Echavarria-Pinto, Matthew J Shun-Shin, James P Howard, Christopher M Cook, Takayuki Warisawa and 18 more

Open access · greenAbstract read
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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  10. A Vessel-Specific Analysis of Deferred Lesions Using the Instantaneous Wave-Free Ratio and Fractional Flow Reserve.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 7 institutions in 3 countries.

Henry SeligmanNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Sukhjinder S NijjerNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Tim P van de HoefAcademic Medical Centre, Amsterdam, the Netherlands.
Guus A de WaardVU University Medical Center, Amsterdam, the Netherlands.
Hernán Mejía-RenteríaHospital Clínico San Carlos IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
Mauro Echavarria-PintoVU University Medical Center, Amsterdam, the Netherlands.
Matthew J Shun-ShinNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
James P HowardNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Christopher M CookNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Takayuki WarisawaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Yousif AhmadNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Vitaliy AndroshchukBuckinghamshire Healthcare NHS Trust, Amersham, United Kingdom.
Christopher RajkumarNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Alexandra NowbarNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mihir A KelshikerNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Martijn A van LavierenAcademic Medical Centre, Amsterdam, the Netherlands.
Martijn MeuwissenDepartment of Cardiology, Amphia Hospital, Breda, the Netherlands.
Ibrahim DanadAcademic Medical Centre, Amsterdam, the Netherlands.
Paul KnaapenVU University Medical Center, Amsterdam, the Netherlands.
Sayan SenNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Rasha Al-LameeNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Jamil MayetNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Javier EscanedHospital Clínico San Carlos IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
Jan J PiekAcademic Medical Centre, Amsterdam, the Netherlands.
Niels van RoyenDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Justin E DaviesNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Darrel P FrancisNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ricardo PetracoNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Imperial College London · GBAcademic Medical Center · NLAmsterdam UMC Location VUmc · NLUniversidad Complutense de Madrid · ESAmphia Ziekenhuis · NLBuckinghamshire Healthcare NHS Trust · GBRadboud University Medical Center · NL

Funding

British Heart Foundation FS/ICRF/22/26039Medical Research Council MR/S021108/1Wellcome Trust
6 · The paper itself

Abstract

backgroundCoronary blood flow in humans is known to be predominantly diastolic. Small studies in animals and humans suggest that this is less pronounced or even reversed in the right coronary artery (RCA).

aimsThis study aimed to characterise the phasic patterns of coronary flow in the left versus right coronary arteries of patients undergoing invasive physiological assessment.

methodsWe analysed data from the Iberian-Dutch-English Collaborators (IDEAL) study. A total of 482 simultaneous pressure and flow measurements from 301 patients were included in our analysis.

resultsOn average, coronary flow was higher in diastole both at rest and during hyperaemia in both the RCA and LCA (mean diastolic-to-systolic velocity ratio [DSVR] was, respectively, 1.85±0.70, 1.76±0.58, 1.53±0.34 and 1.58±0.43 for LCA

conclusionsIn patients with coronary artery disease undergoing physiological assessment, diastolic flow predominance is seen in both left and right coronary arteries. Clinical interpretation of coronary physiological data should therefore not differ between the left and the right coronary systems.

Indexed as

Coronary VesselsHyperemiaBlood Flow VelocityConstriction, PathologicCoronary CirculationDiastoleHumans

Identifiers

PMID34338643
PMCPMC9724998
OpenAlexW3189302924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.