Evidence map›Paper›PMID 34338483›Full record

ArticleJBRA assisted reproduction2022

Duration-dependent effects of high dose of phthalate exposure on semen quality in adult male rats.

Victor Emojevwe, Alexander O Naiho, Eze K Nwangwa, Mega O Oyovwi, Kenneth K Anachuna, Ejime Agbanifo-Chijiokwu, Terela M E Daubry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBRA assisted reproduction, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Victor EmojevweDelta State University, Abraka, Delta State, Nigeria.
Alexander O NaihoDelta State University, Abraka, Delta State, Nigeria.
Eze K NwangwaDelta State University, Abraka, Delta State, Nigeria.
Mega O OyovwiDelta State University, Abraka, Delta State, Nigeria.
Kenneth K AnachunaDelta State University, Abraka, Delta State, Nigeria.
Ejime Agbanifo-ChijiokwuDelta State University, Abraka, Delta State, Nigeria.
Terela M E DaubryDelta State University, Abraka, Delta State, Nigeria.
Delta State University · NGAchievers University · NGOndo State University of Science and Technology · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the length of exposure to high doses of phthalate that might affect sperm quality in adult male Wistar rats.

methodsForty-two (42) adult male Wistar rats (weighing 150-200 g) were randomly assigned into six groups (n=7): Group A received 0.5 mL of distilled water - placebo - and served as controls; groups B, C, D, E and F received Phthalate (750 mg/kgbw) for 1, 3, 5, 7 and 9 weeks, respectively. The data obtained from the study was expressed as Mean ± SEM with a p-value <0.05 considered significant. The data was analyzed with one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test using GraphPad Prism, version 8.

resultsThe results showed a statistically significant (p<0.05) decrease in testicular weight in the rats exposed to 750 mg/kg of phthalate for 3, 5, 7 and 9 weeks when compared with the controls. Sperm count, motility and viability were also significantly (p<0.05) reduced, while sperm cells with abnormal morphology had increased counts in the groups exposed for 3, 5, 7 and 9 weeks when compared with controls. Serum zinc and magnesium were also significantly reduced (p<0.05) in the subjects treated for 1, 3, 5, 7 and 9 weeks when compared with controls.

conclusionsThe dosage of phthalate adopted in this study was deleterious to testicular function when rats were exposed to it for as short a period as three weeks.

Indexed as

Semen AnalysisSperm MotilityAnimalsMalePhthalic AcidsRatsRats, WistarSpermatozoaSperm Countphthalic acidPhthalic Acidsmorphologymotilityphthalatesperm countsperm viabilitytesticular toxicity

Identifiers

PMID34338483
PMCPMC8769194
OpenAlexW3192267345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.