Evidence map›Paper›PMID 34338380›Full record

SynthesisReviews in medical virology2022

Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?

João Locke Ferreira de Araújo, Diego Menezes, Julia Maria Saraiva-Duarte, Luciana de Lima Ferreira, Renato Santana de Aguiar, Renan Pedra de Souza

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Reviews in medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Frontiers in genetics · 2022
    Pooled it
  4. Editorial: Global excellence in virology: Latin America.Frontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Experimental and therapeutic medicine · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Locke Ferreira de AraújoLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-9469-9673
Diego MenezesLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-9603-455X
Julia Maria Saraiva-DuarteLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-7742-3210
Luciana de Lima FerreiraLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-4507-8261
Renato Santana de AguiarLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-5180-3717
Renan Pedra de SouzaLaboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-9479-4432

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais
6 · The paper itself

Abstract

Biomarker identification may provide strategic opportunities to understand disease pathophysiology, predict outcomes, improve human health, and reduce healthcare costs. The highly heterogeneous Covid-19 clinical manifestation suggests a complex interaction of several different human, viral and environmental factors. Here, we systematically reviewed genetic association studies evaluating Covid-19 severity or susceptibility to SARS-CoV-2 infection following PRISMA recommendations. Our research comprised papers published until December 31

Indexed as

COVID-19HumansInterferon LambdaInterleukinsMembrane ProteinsPrognosisRNA-Binding ProteinsSARS-CoV-2IFITM3 protein, humanIFNL4 protein, humanInterferon LambdaInterleukinsMembrane ProteinsRNA-Binding Proteinscandidate genetic variantsCovid-19genetic associationpolymorphismsSARS-CoV-2susceptibility

Identifiers

PMID34338380
PMCPMC8420453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.