ArticleAmerican journal of physiology. Endocrinology and metabolism2021
Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice.
Article in American journal of physiology. Endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Ferroptosis-driven immune remodeling in heart failure: the central role of macrophage reprogramming and impaired efferocytosis.Journal of nanobiotechnology · 2026Review
- Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations.Cancer research · 2025Article
- Combined effects of genetic background and diet on mouse metabolism and gene expression.iScience · 2024Article
- Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice.Diabetes · 2024Article
- Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations.bioRxiv : the preprint server for biology · 2024Article
- Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice.bioRxiv : the preprint server for biology · 2024Article
- Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility.Cell death discovery · 2023Review
- The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism.Nature reviews. Endocrinology · 2022Review
- Exon 2-mediated deletion of Trem2 does not worsen metabolic function in diet-induced obese mice.The Journal of physiology · 2022Article
- An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload.International journal of molecular sciences · 2022Article
- Targeted delivery of nanomedicines for promoting vascular regeneration in ischemic diseases.Theranostics · 2022Review
- Macrophages and Iron: A Special Relationship.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood. Macrophages (Mɸs) are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mɸs impairs mitochondrial energetics and evokes systemic insulin resistance in mice. Male and female mice with myeloid-targeted (LysMCre) deletion of the canonical iron exporter, ferroportin (Fpn, encoded by
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Registered trials
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