Evidence map›Paper›PMID 34338032›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Patterns of differentiation of renin lineage cells during nephrogenesis.

Friederike Kessel, Anne Steglich, Linda Hickmann, Ricardo Lira Martinez, Michael Gerlach, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Christian P M Hugo, Vladimir T Todorov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Flexible and multifaceted: the plasticity of renin-expressing cells.Pflugers Archiv : European journal of physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Friederike KesselExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Anne SteglichExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Linda HickmannExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Ricardo Lira MartinezExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Michael GerlachExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia.
R Ariel GomezDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia.
Christian P M HugoExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Vladimir T TodorovExperimental Nephrology, Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.ORCID 0000-0002-7011-8130
University Hospital Carl Gustav Carus · DEUniversity of Virginia · US

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
Fate of the kidney vasculature during partial neonatal ureteral obstructionR01DK116196 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2021
$1.5M
2018 Angiotensin Gordon Research Conference & Gordon Research SeminarR13HL140842 · NHLBI · GORDON RESEARCH CONFERENCES · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2018
$30k
NHLBI NIH HHS R01 HL148044NHLBI NIH HHS R13 HL140842NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116196
6 · The paper itself

Abstract

Developmentally heterogeneous renin-expressing cells serve as progenitors for mural, glomerular, and tubular cells during nephrogenesis and are collectively termed renin lineage cells (RLCs). In this study, we quantified different renal vascular and tubular cell types based on specific markers and assessed proliferation and de novo differentiation in the RLC population. We used kidney sections of mRenCre-mT/mG mice throughout nephrogenesis. Marker positivity was evaluated in whole digitalized sections. At

Indexed as

AnimalsCell DifferentiationCell LineageKidneyKidney GlomerulusMesangial CellsMesodermMiceReninStem CellsRenindifferentiationimmunofluorescencenephrogenesisrenin lineage cells

Identifiers

PMID34338032
PMCPMC8906827
OpenAlexW3190515342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.