Evidence map›Paper›PMID 34337899›Full record

ArticlePhysiological reports2021

A NEW approach for characterizing mouse urinary pathophysiologies.

Hannah M Ruetten, Gervaise H Henry, Teresa T Liu, Heidi M Spratt, William A Ricke, Douglas W Strand, Chad M Vezina

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms.American journal of clinical and experimental urology · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hannah M RuettenDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-6263-6221
Gervaise H HenryUniversity of Wisconsin-Madison/UMASS Boston/UT Southwestern George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Teresa T LiuUniversity of Wisconsin-Madison/UMASS Boston/UT Southwestern George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Heidi M SprattDepartment of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.
William A RickeUniversity of Wisconsin-Madison/UMASS Boston/UT Southwestern George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Douglas W StrandUniversity of Wisconsin-Madison/UMASS Boston/UT Southwestern George M. O'Brien Center for Benign Urologic Research, Madison, WI, USA.
Chad M VezinaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-7058-5399
University of Wisconsin–Madison · USThe University of Texas Medical Branch at Galveston · US

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8M
NRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4M
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DIOXINR01ES001332 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, RICHARD EUGENE, VEZINA, CHAD M. · 1985 to 2021
$5.3M
Impact of age on altered steroidogenesis and estrogen receptor activation in benign prostatic hyperplasia progressionK01AG059899 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LIU, TERESA · 2020 to 2024
$655k
Prostate inflammation increases collagen and voiding dysfunctionF30DK122686 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RUETTEN, HANNAH MARGARET · 2019 to 2022
$157k
NCATS NIH HHS TL1 TR002375NIA NIH HHS K01 AG059899NIDDK NIH HHS F30 DK122686NIDDK NIH HHS U54 DK104310NIEHS NIH HHS R01 ES001332
6 · The paper itself

Abstract

The void spot assay (VSA) is a cost-effective method for evaluating and quantifying mouse urinary voiding phenotypes. The VSA has been used to differentiate voiding behaviors between experimental groups, but not as a diagnostic assay. To build toward this goal, we used the VSA to define voiding patterns of male mice with diabetic diuresis (BTBR.Cg-Lep

Indexed as

DiuresisUrodynamicsAnimalsBiological AssayDiabetes Mellitus, ExperimentalMaleMiceMice, Inbred C57BLMice, ObeseTestosteroneUrinary BladderUrinary Incontinence, StressUrinary Tract InfectionsUrination DisordersTestosteroneanimal modelsbladder outlet obstructiondiabetic diuresisspontaneous void spot assayurinary frequency

Identifiers

PMID34337899
PMCPMC8326900
OpenAlexW3190387680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.