ArticleSchizophrenia bulletin2022
Imbalance Between Prefronto-Thalamic and Sensorimotor-Thalamic Circuitries Associated with Working Memory Deficit in Schizophrenia.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Peripheral inflammation mediates cognitive deficits in drug-naive schizophrenia through hippocampal-thalamo-visual circuitry dysfunction.Schizophrenia (Heidelberg, Germany) · 2026Article
- Association between usage intensity of short video platforms and altered brain function: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Nucleus Reuniens-Elicited Delta Oscillations Disable the Prefrontal Cortex in Schizophrenia.Cells · 2025Review
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study.Schizophrenia (Heidelberg, Germany) · 2025Review
- The effect of implicit learning on functional connectivity in schizophrenia.Frontiers in psychiatry · 2025Article
- Unraveling the Boundaries, Overlaps, and Connections between Schizophrenia and Obsessive-Compulsive Disorder (OCD).Journal of clinical medicine · 2024Review
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Prediction of pharmacological treatment efficacy using electroencephalography-based salience network in patients with major depressive disorder.Frontiers in psychiatry · 2024Article
- Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders.Science advances · 2023Article
- Possible Neuropathological Mechanisms Underlying the Increased Complexity of Brain Electrical Activity in Schizophrenia: A Computational Study.Iranian journal of psychiatry · 2023Article
- Large-Scale Thalamocortical Triple Network Dysconnectivities in Patients With First-Episode Psychosis and Individuals at Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Using support vector machine to explore the difference of function connection between deficit and non-deficit schizophrenia based on gray matter volume.Frontiers in neuroscience · 2023Article
- Trait and state-related characteristics of thalamo-cortical circuit disruption in bipolar disorder: a prospective cross-sectional study.Frontiers in psychiatry · 2023Article
- The thalamus in psychosis spectrum disorder.Frontiers in neuroscience · 2023Article
- The role of thalamic group II mGlu receptors in health and disease.Neuronal signaling · 2022Review
- Article
- Decreased integration of default-mode network during a working memory task in schizophrenia with severe attention deficits.Frontiers in cellular neuroscience · 2022Article
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12 authors.
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Abstract
backgroundThalamocortical circuit imbalance characterized by prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity has been consistently documented at rest in schizophrenia (SCZ). However, this thalamocortical imbalance has not been studied during task engagement to date, limiting our understanding of its role in cognitive dysfunction in schizophrenia.
methodsBoth n-back working memory (WM) task-fMRI and resting-state fMRI data were collected from 172 patients with SCZ and 103 healthy control subjects (HC). A replication sample with 49 SCZ and 48 HC was independently obtained. Sixteen thalamic subdivisions were employed as seeds for the analysis.
resultsDuring both task-performance and rest, SCZ showed thalamic hyperconnectivity with sensorimotor cortices, but hypoconnectivity with prefrontal-cerebellar regions relative to controls. Higher sensorimotor-thalamic connectivity and lower prefronto-thalamic connectivity both relate to poorer WM performance (lower task accuracy and longer response time) and difficulties in discriminating target from nontarget (lower d' score) in n-back task. The prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity were anti-correlated both in SCZ and HCs; this anti-correlation was more pronounced with less cognitive demand (rest>0-back>2-back). These findings replicated well in the second sample. Finally, the hypo- and hyper-connectivity patterns during resting-state positively correlated with the hypo- and hyper-connectivity during 2-back task-state in SCZ respectively.
conclusionsThe thalamocortical imbalance reflected by prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity is present both at rest and during task engagement in SCZ and relates to working memory performance. The frontal reduction, sensorimotor enhancement pattern of thalamocortical imbalance is a state-invariant feature of SCZ that affects a core cognitive function.
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