Evidence map›Paper›PMID 34337605›Full record

ArticleJACS Au2021

Mn- and Co-Catalyzed Aminocyclizations of Unsaturated Hydrazones Providing a Broad Range of Functionalized Pyrazolines.

Moritz Balkenhohl, Sebastian Kölbl, Tony Georgiev, Erick M Carreira

Abstract read
In one paragraph

Article in JACS Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moritz BalkenhohlLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland.
Sebastian KölblLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland.
Tony GeorgievLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland.
Erick M CarreiraLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland.ORCID https://orcid.org/0000-0003-1472-490X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manganese- and cobalt-catalyzed aminocyclization reactions of unsaturated hydrazones are reported. Whereas manganese catalysis provides access to pyrazoline and tetrahydropyridazine alcohols, cobalt catalysis for the first time paves the way for the selective formation of pyrazoline aldehydes. Furthermore, various functional groups including hydroperoxide, thiol derivatives, iodide, and bicyclopentane may be introduced via manganese-catalyzed ring-forming aminofunctionalization. A progesterone receptor antagonist was prepared using the aminocyclization protocol.

Identifiers

PMID34337605
PMCPMC8317158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.