ArticleCell reports. Medicine2021
An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions.
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Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Advancements in differentiation of induced pluripotent stem cells into specialized neuronal subtypes.Neural regeneration research · 2026Article
- Rapid generation of human sensory neurons from iPSC for modeling of peripheral neuropathies.Journal of neuroscience methods · 2026Article
- Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model.Brain : a journal of neurology · 2026Article
- Lipid alterations in hereditary peripheral neuropathies: common mechanisms in disease heterogeneity?Molecular neurodegeneration · 2026Review
- Metabolic signatures in sciatic nerve of PMP22 transgenic rats provide insights into the pathogenesis of charcot-marie-tooth disease type 1 A.Scientific reports · 2026Article
- NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons.Journal of neuroinflammation · 2025Article
- Blood 1-Deoxysphingolipid Levels Are Associated With Epidermal Denervation in Small Fiber Neuropathy.Journal of the peripheral nervous system : JPNS · 2025Article
- Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy.Annals of clinical and translational neurology · 2025Review
- Modelling inflammation-induced peripheral sensitization in a dish-more complex than expected?Pain · 2025Article
- Human genetic defects of sphingolipid synthesis.Journal of inherited metabolic disease · 2025Review
- SPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis.Cell reports · 2024Article
- Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons.Stem cell reports · 2024Article
- Advances and challenges in modeling inherited peripheral neuropathies using iPSCs.Experimental & molecular medicine · 2024Review
- Human sensory-like neuron cultivation-An optimized protocol.Frontiers in neuroscience · 2024Article
- Serine Palmitoyltransferase (SPT)-related Neurodegenerative and Neurodevelopmental Disorders.Journal of neuromuscular diseases · 2024Review
- Predicting 'pain genes': multi-modal data integration using probabilistic classifiers and interaction networks.Bioinformatics advances · 2024Article
- A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.Science translational medicine · 2023Article
- Article
- Towards bridging the translational gap by improved modeling of human nociception in health and disease.Pflugers Archiv : European journal of physiology · 2022Review
- Neurological update: hereditary neuropathies.Journal of neurology · 2022Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Alex J ClarkNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Umaiyal KugathasanCentre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
Georgios BaskozosNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
David A PriestmanDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Nadine FuggerNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Museer A LoneInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Alaa OthmanInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Ka Hing ChuNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Iulia BlesneacNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Emma R WilsonCentre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
Matilde LauràCentre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
Bernadett KalmarDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Linda GreensmithCentre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
Thorsten HornemannInstitute of Clinical Chemistry, University Hospital Zurich, 8091 Zurich, Switzerland.
Frances M PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Mary M ReillyCentre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.
David L BennettNeural Injury Group, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
University of Oxford · GBNational Hospital for Neurology and Neurosurgery · GBUniversity College London · GBUniversity Hospital of Zurich · CHJohn Radcliffe Hospital · GB
Funding
trainingU54NS065712 · NINDS · WAYNE STATE UNIVERSITY · PI SHY, MICHAEL E. · 2009 to 2023
$19.6MNINDS NIH HHS U54 NS065712Wellcome Trust 202747/Z/16/ZWellcome Trust 202834/Z/16/Z
Abstract
Hereditary sensory neuropathy type 1 (HSN1) is caused by mutations in the
Indexed as
Models, BiologicalAgingAxonsBase SequenceCaspase 3Cell LineGangliosidesGene Expression RegulationHereditary Sensory and Autonomic NeuropathiesHumansInduced Pluripotent Stem CellsMembrane MicrodomainsMyelin SheathNerve Growth FactorsNeurogliaNeuronal OutgrowthCaspase 3GangliosidesNerve Growth FactorsNodal ProteinSerineSphingolipids1-deoxySLBsaxonDSBsgangliosidehereditary sensory neuropathy type 1HSN1l-serinemyelinsensory neuronserine palmitoyltransferaseserine palmitoyltransferase long-chain base subunit 1sphingolipidSPTSPTLC1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.