Evidence map›Paper›PMID 34337558›Full record

ArticleCell reports. Medicine2021

Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity.

Andreas G Wibmer, Tobias Becher, Mahmoud Eljalby, Audrey Crane, Pamela Causa Andrieu, Caroline S Jiang, Roger Vaughan, Heiko Schöder, Paul Cohen

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

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  20. Macrophages in metaflammation - fueling chronic inflammation in metabolic disease.Pflugers Archiv : European journal of physiology · 2025
    Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Andreas G WibmerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tobias BecherLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
Mahmoud EljalbyLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
Audrey CraneLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
Pamela Causa AndrieuDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Caroline S JiangCenter for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
Roger VaughanCenter for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USRockefeller University · USCornell University · USHeidelberg University · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Stable Isotope and Metabolomics CoreP60DK020541 · NIDDK · YESHIVA UNIVERSITY · PI FLEISCHER, NORMAN S. · 1986 to 2014
$29.8M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7M
NCATS NIH HHS UL1 TR001866NCI NIH HHS P30 CA008748NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P60 DK020541
6 · The paper itself

Abstract

The association of brown adipose tissue (BAT) and body fat distribution and their combined effects on metabolic health in humans remains unknown. Here, we retrospectively identify individuals with and without BAT on

Indexed as

Body Fat DistributionAdipose Tissue, BrownAdiposityCohort StudiesDiabetes Mellitus, Type 2Fatty LiverFemaleFluorodeoxyglucose F18HumansLiverMaleMetabolomeMiddle AgedMultivariate AnalysisPositron Emission Tomography Computed TomographyFluorodeoxyglucose F18brown adipose tissuebrown fatglucose metabolismhepatic steatosislipid metabolismmetabolic healthsubcutaneous fattype 2 diabetes mellitusvisceral fatvisceral obesity

Identifiers

PMID34337558
PMCPMC8324464
OpenAlexW3181138432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.