Evidence map›Paper›PMID 34337555›Full record

ArticleCell reports. Medicine2021

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection in fetuses.

Manukumar Honnayakanahalli Marichannegowda, Michael Mengual, Amit Kumar, Elena E Giorgi, Joshua J Tu, David R Martinez, Ethan O Romero-Severson, Xiaojun Li, Liping Feng, Sallie R Permar and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Manukumar Honnayakanahalli MarichannegowdaDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Michael MengualDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Amit KumarDuke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Elena E GiorgiTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
Joshua J TuDuke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
David R MartinezDuke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
Ethan O Romero-SeversonTheoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
Xiaojun LiDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Liping FengDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
Sallie R PermarDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Feng GaoDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Duke Medical Center · USLos Alamos National Laboratory · USJinan University · CN

Funding

PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7M
Pediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7M
Identifying key determinants of IgG transplacental transfer from HIV-infected mothers to their fetusF31AI127303 · NIAID · DUKE UNIVERSITY · PI MARTINEZ, DAVID R. · 2017 to 2018
$50k
NIAID NIH HHS F31 AI127303NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itself

Abstract

Study of evolution and selection pressure on HIV-1 in fetuses will lead to a better understanding of the role of immune responses in shaping virus evolution and vertical transmission. Detailed genetic analyses of HIV-1

Indexed as

Biological EvolutionInfectious Disease Transmission, VerticalMothersAdolescentAdultBase SequenceCell Lineenv Gene Products, Human Immunodeficiency VirusFemaleFetusGenetic VariationHIV-1HIV InfectionsHost-Pathogen InteractionsHumansInfant, Newbornenv Gene Products, Human Immunodeficiency VirusfetusHIV-1immune selectionin utero transmissionmother to child transmissionneonatesignature

Identifiers

PMID34337555
PMCPMC8324465
OpenAlexW3214517857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.