Evidence map›Paper›PMID 34337522›Full record

ArticleEuropean urology open science2021

Loes F M van der Zanden, Iris A L M van Rooij, Josine S L T Quaedackers, Rien J M Nijman, Martijn Steffens, Liesbeth L L de Wall, Ernie M H F Bongers, Franz Schaefer, Marietta Kirchner, Rouven Behnisch and 14 more

Open access · goldAbstract read
In one paragraph

Article in European urology open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Risk stratification for children with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 13 institutions in 6 countries.

Loes F M van der ZandenRadboud Institute for Health Sciences, Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands.
Iris A L M van RooijRadboud Institute for Health Sciences, Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands.
Josine S L T QuaedackersDepartment of Urology, University Medical Center Groningen, Groningen, The Netherlands.
Rien J M NijmanDepartment of Urology, University Medical Center Groningen, Groningen, The Netherlands.
Martijn SteffensDepartment of Urology, Isala, Zwolle, The Netherlands.
Liesbeth L L de WallRadboud Institute for Molecular Life Sciences, Division of Pediatric Urology, Department of Urology, Radboudumc Amalia Children's Hospital, Nijmegen, The Netherlands.
Ernie M H F BongersRadboud Institute for Molecular Life Sciences, Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Franz SchaeferCenter for Pediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Marietta KirchnerInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Rouven BehnischInstitute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Aysun K BayazitDepartment of Pediatric Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Salim CaliskanDepartment of Pediatric Nephrology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Lukasz ObryckiDepartment of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Giovanni MontiniPediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Ali DuzovaDivision of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Matthias WuttkeInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Rachel JenningsFaculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
Neil A HanleyFaculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
Natalie J MilmoeNephro-Urology Research Group, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
Paul J D WinyardNephro-Urology Research Group, Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK.
Kirsten Y RenkemaDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Michiel F SchreuderRadboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Radboudumc Amalia Children's Hospital, Nijmegen, The Netherlands.
Nel RoeleveldRadboud Institute for Health Sciences, Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands.
Wout F J FeitzRadboud Institute for Molecular Life Sciences, Division of Pediatric Urology, Department of Urology, Radboudumc Amalia Children's Hospital, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLHeidelberg University · DEGreat Ormond Street Hospital · GBManchester Academic Health Science Centre · GBUniversity Medical Center Groningen · NLChildren's Memorial Health Institute · PLCukurova University · TRHacettepe University · TRIsala · NLIstanbul University-Cerrahpaşa · TRUniversity of Freiburg · DEUniversity of Milan · ITUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development.

objectiveTo identify genetic variants associated with kidney injury in patients with obstructive uropathy. DESIGN SETTING AND

participantsWe included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Signs of kidney injury were defined as dialysis, nephrectomy, kidney transplantation, estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m RESULTS AND LIMITATIONS: Despite the small and nonhomogeneous sample, we observed suggestive associations for six SNPs in three loci, of which rs6874819 in the

conclusionsThis study identified PATIENT SUMMARY: We found that variants of the

Indexed as

CDH12Genome-wide association studyObstructive uropathyPosterior urethral valves

Identifiers

PMID34337522
PMCPMC8317879
OpenAlexW3159939264

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.