ArticleEuropean urology open science2021
Photodynamic Diagnosis-guided Dual Laser Ablation for Upper Urinary Tract Carcinoma: Preoperative Preparation, Surgical Technique, and Clinical Outcomes.
Article in European urology open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Enhanced Endoscopic Imaging Technologies in Upper Urinary Tract Urothelial Tumors: Implications for Kidney-Sparing Surgery-A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Fluorescent Ureterorenoscopy-Assisted Thulium:YAG and Holmium:YAG Dual-Laser Ablation for Upper Urinary Tract Urothelial Carcinoma: Results of the FLUAM Trial.Annals of surgical oncology · 2026Article
- Recurrence and timing of conversion to radical nephroureterectomy after endoscopic laser ablation for upper tract urothelial carcinoma: a multicenter Japanese study.Translational andrology and urology · 2026Article
- Review
- Ipsilateral recurrences after kidney-sparing surgery for upper tract urothelial carcinoma: a systematic review and meta-analysis.BMJ oncology · 2026Article
- Kidney-sparing approach for upper tract urothelial carcinoma: An update on current evidence.Asian journal of urology · 2025Review
- Reply to: "Photodynamic Diagnosis-Guided Ureteroscopic Laser Ablation of Upper Tract Urothelial Carcinoma: Some Concerns and Future Direction".Annals of surgical oncology · 2025Article
- Photodynamic Diagnosis-Guided Ureteroscopic Laser Ablation of Upper Tract Urothelial Carcinoma: Some Concerns and Future Direction.Annals of surgical oncology · 2025Article
- Photodynamic Diagnosis-Guided Ureteroscopic Laser Ablation of Upper Urinary Tract Urothelial Carcinoma: Phase 2, Open-Label, Single-Arm Trial.Annals of surgical oncology · 2025Article
- Navigating the Aftermath: A Comprehensive Scoping Review on Follow-up Strategies After Kidney-sparing Surgery for Upper Tract Urothelial Carcinoma.European urology open science · 2024Article
- Development and Validation of a Preoperative Nomogram for Endoscopic Management Decision Making in Upper Urinary Tract Urothelial Carcinoma.Annals of surgical oncology · 2024Article
- 450-nm blue diode laser: a novel medical apparatus for upper tract urothelial lesions.World journal of urology · 2023Article
- Novel laser therapies and new technologies in the endoscopic management of upper tract urothelial carcinoma: a narrative review.Translational andrology and urology · 2023Review
- A Review of How Lasers Are Used in UTUC Surgery: Can the Choice of Laser Affect Outcomes?Cancers · 2023Review
- A prospective, single-arm trial of fluorescent ureteroscopy-assisted thulium-holmium:YAG dual laser ablation for upper urinary tract cancer: Study protocol of the FLUAM trial.Contemporary clinical trials communications · 2022Article
- The role of endoscopic management and adjuvant topical therapy for upper tract urothelial cancer.Frontiers in urology · 2022Article
- Assessment of the Diagnostic Value of the UF-5000 Parameter Atyp.C in Upper Tract Urothelial Carcinoma.Cancer diagnosis & prognosisArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough ureteroscopic surgery (URS) is beneficial for low-risk upper urinary tract carcinoma (UTUC), there is no standardized URS technique or navigation system for challenging cases.
objectiveTo present a URS technique for UTUC using thulium (Tm):YAG and holmium (Ho):YAG lasers under photodynamic diagnosis (PDD) guidance, named PDD-guided dual laser ablation (PDD-DLA) and compare its efficacy with that of conventional Ho:YAG laser ablation (HLA; historical control). DESIGN SETTING AND
participantsThe study included ten consecutive UTUC patients who underwent PDD-DLA between 2017 and 2019. The control group comprised 16 consecutive patients who underwent HLA between 2006 and 2016. SURGICAL PROCEDURE: After oral administration of 5-aminolevulinic acid (20 mg/kg), UTUC tumors were endoscopically resected via PDD-DLA. MEASUREMENTS: Clinical data were prospectively collected for our institutional UTUC data set. Disease progression, UTUC recurrence, and clinical outcomes were assessed. RESULTS AND LIMITATIONS: PDD-DLA was successfully performed in all patients. The median tumor size was 23.5 mm (interquartile range [IQR] 12.8-30.0) and there were four cases (40.0%) of high-grade tumor. The median operative time was 120 min (IQR 98.5-142.5). No Clavien-Dindo grade ≥3 complications were observed. There were no differences in most clinical characteristics between the PDD-DLA and HLA groups. The 2-yr progression-free survival rate was 100% in the PDD-DLA group and 58.7% in the HLA group (
conclusionsPDD-DLA seems to be an effective and feasible endoscopic technique for UTUC treatment with favorable oncological outcomes. PATIENT SUMMARY: We investigated a new laser technique for treating cancer of the upper urinary tract called photodynamic diagnosis-guided dual laser ablation. Our strategy was effective in removing tumors and stopping bleeding. Further studies in larger groups of patients are needed to confirm whether this technique improves cancer outcomes.
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