Evidence map›Paper›PMID 34337482›Full record

ArticleEuropean urology open science2020

In Situ Metabolomics Expands the Spectrum of Renal Tumours Positive on

Thomas Papathomas, Antonios Tzortzakakis, Na Sun, Franziska Erlmeier, Annette Feuchtinger, Kiril Trpkov, Alina Bazarova, Alexandros Arvanitis, Wanzhong Wang, Bela Bozoky and 3 more

Open access · goldAbstract read
In one paragraph

Article in European urology open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Thomas PapathomasInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Antonios TzortzakakisDivision of Radiology, Department for Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Na SunResearch Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Munich, Germany.
Franziska ErlmeierInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Annette FeuchtingerResearch Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Munich, Germany.
Kiril TrpkovDepartment of Pathology and Laboratory Medicine, Alberta Precision Labs, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Alina BazarovaInstitute for Biological Physics, University of Cologne, Cologne, Germany.
Alexandros ArvanitisDepartment of Clinical Pathology and Cytology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Wanzhong WangDepartment of Clinical Pathology and Cytology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Bela BozokyDepartment of Clinical Pathology and Cytology, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Georgia KokarakiDepartment of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden.
Rimma AxelssonDivision of Radiology, Department for Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Axel WalchResearch Unit Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München, Munich, Germany.
Karolinska University Hospital · SEHelmholtz Zentrum München · DECheltenham General Hospital · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Calgary · CAUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDefinite noninvasive characterisation of renal tumours positive on

objectiveTo investigate whether combined DESIGN SETTING AND

participantsA tissue microarray analysis of 33 tumour samples from 28 patients was used to investigate whether their in situ metabolomic status correlates with their features on OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: MALDI MSI data analysis and image generation were facilitated by FlexImaging v. 4.2, while k-means analysis by SCiLS Lab software followed by R-package CARRoT analysis was used for assessing the highest predictive power in the differential of RO versus chRCC. Heatmap-based clustering, sparse partial least-squares discriminant analysis, and volcano plots were created with MetaboAnalyst 3.0. RESULTS AND LIMITATIONS: We identified a discriminatory metabolomic signature for

conclusionsThe current study expands the spectrum of PATIENT SUMMARY: For preoperative evaluation of solid renal tumours,

Indexed as

99mTc-sestamibi SPECT/CTRenal tumour/in situ metabolomics

Identifiers

PMID34337482
PMCPMC8317898
OpenAlexW3107960522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.