Evidence map›Paper›PMID 34337361›Full record

ArticleiScience2021

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation.

Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont and 9 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Lise Van WyngeneCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Tineke VanderhaeghenCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Ioanna PettaCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Steven TimmermansCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Katrien CorbeelsDepartment of Chronic Diseases and Metabolism - Endocrinology, KU Leuven, Leuven, Belgium.
Bart Van der SchuerenDepartment of Chronic Diseases and Metabolism - Endocrinology, KU Leuven, Leuven, Belgium.
Jolien VandewalleCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Kelly Van LooverenCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Charlotte WallaeysCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Melanie EggermontCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Sylviane DewaeleCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Leen CatrysseCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Geert van LooCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Rudi BeyaertCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Roman VangoitsenhovenDepartment of Chronic Diseases and Metabolism - Endocrinology, KU Leuven, Leuven, Belgium.
Toshinori NakayamaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Jan TavernierCenter for Medical Biotechnology, VIB Center for Medical Biotechnology, 9000 Ghent, Belgium.
Karolien De BosscherCenter for Medical Biotechnology, VIB Center for Medical Biotechnology, 9000 Ghent, Belgium.
Claude LibertCenter for Inflammation Research, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Ghent University · BEKU Leuven · BEChiba University · JPGhent University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body's response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 32 (ZBTB32) is a transcription factor with poorly described functional relevance in physiology. This study shows that ZBTB32 is essential for the production of glucocorticoids (GCs) in response to starvation, since ZBTB32

Indexed as

animal physiologybiological sciencesEndocrinologyphysiology

Identifiers

PMID34337361
PMCPMC8324811
OpenAlexW3174524730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.