Evidence map›Paper›PMID 34337344›Full record

ArticleACS applied nano materials2020

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma.

Xiaohui Zhang, Dezhuang Ye, Lihua Yang, Yimei Yue, Deborah Sultan, Christopher Pham Pacia, Hannah Pang, Lisa Detering, Gyu Seong Heo, Hannah Luehmann and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Focused ultrasound in pediatric neurosurgery: a scoping review of opportunities and challenges.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Xiaohui Zhang *Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9259-5093
Dezhuang Ye *Department of Mechanical Engineering and Material Science, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Lihua YangDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yimei YueDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Deborah SultanMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Christopher Pham PaciaDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Hannah PangDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Lisa DeteringMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hannah LuehmannMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ankur ChoksiSchool of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
Abhishek SethiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
David D LimbrickDepartment of Neurosurgery, Washington University in St. Louis, Saint Louis, MO 63110, USA.
Oren J BecherDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Yuan-Chuan TaiMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua B RubinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1118-1535
Mallinckrodt (United States) · USWashington University in St. Louis · USNorthwestern University · USUniversity of Maryland, Baltimore · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
NCI NIH HHS P30 CA091842NIBIB NIH HHS R01 EB027223NIMH NIH HHS R01 MH116981
6 · The paper itself

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (

Indexed as

diffuse intrinsic pontine gliomafocused ultrasoundmagnetic resonance imagingnanoclusterspositron emission tomography

Identifiers

PMID34337344
PMCPMC8320805
OpenAlexW3096050902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.