ArticleJOR spine2021
Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain.
Article in JOR spine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration.JOR spine · 2026Article
- Degeneration-Driven and Load-Modulated Fluid-Driven Viscoelasticity of the Human Intervertebral Disc: A Probabilistic Biphasic Swelling Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
- Global and local identifiability analysis of a nonlinear biphasic constitutive model in confined compression.Journal of the Royal Society, Interface · 2024Article
- Residual Strain and Joint Pressurization Maintain Collagen Tension for On-Joint Lumbar Facet Capsular Ligaments.Journal of biomechanical engineering · 2024Article
- Article
- Neural network segmentation of disc volume from magnetic resonance images and the effect of degeneration and spinal level.JOR spine · 2024Article
- Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?JOR spine · 2024Article
- Geometric determinants of the mechanical behavior of image-based finite element models of the intervertebral disc.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Validation and Estimation of Obesity-Induced Intervertebral Disc Degeneration through Subject-Specific Finite Element Modelling of Functional Spinal Units.Bioengineering (Basel, Switzerland) · 2024Article
- A Review of CT-Based Fracture Risk Assessment with Finite Element Modeling and Machine Learning.Current osteoporosis reports · 2022Review
- Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain.JOR spine · 2021Article
- Sensitivity of Intervertebral Disc Finite Element Models to Internal Geometric and Non-geometric Parameters.Frontiers in bioengineering and biotechnology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Finite element models of the intervertebral disc are used to address research questions that cannot be tested through typical experimentation. A disc model requires complex geometry and tissue properties to be accurately defined to mimic the physiological disc. The physiological disc possesses residual strain in the annulus fibrosus (AF) due to osmotic swelling and due to inherently pre-strained fibers. We developed a disc model with residual contributions due to swelling-only, and a multigeneration model with residual contributions due to both swelling and AF fiber pre-strain and validated it against organ-scale uniaxial, quasi-static and multiaxial, dynamic mechanical tests. In addition, we demonstrated the models' ability to mimic the opening angle observed following radial incision of bovine discs. Both models were validated against organ-scale experimental data. While the swelling only model responses were within the experimental 95% confidence interval, the multigeneration model offered outcomes closer to the experimental mean and had a bovine model opening angle within one SD of the experimental mean. The better outcomes for the multigeneration model, which allowed for the inclusion of inherently pre-strained fibers in AF, is likely due to its uniform fiber contribution throughout the AF. We conclude that the residual contribution of pre-strained fibers in the AF should be included to best simulate the physiological disc and its behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.