Evidence map›Paper›PMID 34337294›Full record

ReviewAnnals of gastroenterological surgery2021

Recent advances in precision medicine for pancreatic ductal adenocarcinoma.

Hiromitsu Hayashi, Takaaki Higashi, Tatsunori Miyata, Yo-Ichi Yamashita, Hideo Baba

Open access · goldAbstract readReview
In one paragraph

Review in Annals of gastroenterological surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  12. Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography - the next dimension of diagnosis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hiromitsu HayashiDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan.ORCID https://orcid.org/0000-0002-1832-4287
Takaaki HigashiDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan.
Tatsunori MiyataDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan.
Yo-Ichi YamashitaDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan.ORCID https://orcid.org/0000-0001-8439-6660
Hideo BabaDepartment of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan.ORCID https://orcid.org/0000-0002-3474-2550
Kumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer mortality worldwide. Although advances in systemic chemotherapy for PDAC have improved survival outcomes for patients with the disease, chemoresistance is a major treatment issue for unselected PDAC patient populations. The existence of heterogeneity caused by a mixture of tumor cells and stromal cells produces chemoresistance and limits the targeted therapy of PDAC. Advances in precision medicine for PDACs according to the genetics and molecular biology of this disease may represent the next alternative approach to overcome the heterogeneity of different patients and improve survival outcomes for this poor prognostic disease. The genetic alteration of PDAC is characterized by four genes that are frequently mutated (

Indexed as

chemotherapygenetic mutationmolecular subtypepancreatic ductal adenocarcinomaprecision medicine

Identifiers

PMID34337294
PMCPMC8316748
OpenAlexW3127707396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.