Evidence map›Paper›PMID 34337266›Full record

ArticleACS omega2021

Synthesis of Conformationally Liberated Yohimbine Analogues and Evaluation of Cytotoxic Activity.

Han Yang, Michal Poznik, Shaojian Tang, Peng Xue, Lidong Du, Chenlu Liu, Xiaochuan Chen, Jason J Chruma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Han YangKey Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Sciences & Technology, Sichuan University, Chengdu, Sichuan 610064, P. R. China.
Michal PoznikKey Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Sciences & Technology, Sichuan University, Chengdu, Sichuan 610064, P. R. China.
Shaojian TangSchool of Pharmacy, Weifang Medical University, No. 7166, Baotong West Road, Weifang, Shandong 261053, P. R. China.
Peng XueSchool of Public Health, Weifang Medical University, No. 7166, Baotong West Road, Weifang, Shandong 261053, P. R. China.
Lidong DuSchool of Clinical Medicine, Weifang Medical University, No. 7166, Baotong West Road, Weifang, Shandong 261053, P. R. China.
Chenlu LiuKey Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Sciences & Technology, Sichuan University, Chengdu, Sichuan 610064, P. R. China.
Xiaochuan ChenKey Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Sciences & Technology, Sichuan University, Chengdu, Sichuan 610064, P. R. China.ORCID https://orcid.org/0000-0003-3901-0524
Jason J ChrumaKey Laboratory of Green Chemistry & Technology (MOE), College of Chemistry and Sino-British Materials Research Institute, College of Physical Sciences & Technology, Sichuan University, Chengdu, Sichuan 610064, P. R. China.ORCID https://orcid.org/0000-0002-3669-4863
Sichuan University · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A modular synthetic approach to strategically unique structural analogues of the alkaloid yohimbine is reported. The overall synthetic strategy couples the transition-metal-catalyzed decarboxylative allylation of 2,2-diphenylglycinate imino esters with a scandium triflate-mediated highly endo-selective intramolecular Diels-Alder (IMDA) cycloaddition to generate a small collection of de-rigidified yohimbine analogues lacking the ethylene linkage between the indole and decahydroisoquinoline units. One compound generated in this study contains an unprecedented pentacyclic urea core and appears to demonstrate increased cytotoxicity against the gastric cancer cell line SGC-7901 in comparison to a pancreatic cancer cell line (PATU-8988) and a normal human gastric mucosal cell line (GES-1).

Identifiers

PMID34337266
PMCPMC8320076
OpenAlexW3186611049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.