ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Allogeneic mesenchymal stem cell therapy with laromestrocel in mild Alzheimer's disease: a randomized controlled phase 2a trial.Nature medicine · 2025Trial
- Association of Fractional Anisotropy in White Matter Bundles with Plasma Biomarkers of Neurodegeneration and Glial Reactivity in Individuals with Cognitive Complaints without dementia.Research square · 2026Article
- Fibre density and cross-section associate with hallmark pathology in early Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Current Trends and Applications of PET/MRI Hybrid Imaging in Neurodegenerative Diseases and Normal Aging.Diagnostics (Basel, Switzerland) · 2024Review
- Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Application of Deep Learning for Prediction of Alzheimer's Disease in PET/MR Imaging.Bioengineering (Basel, Switzerland) · 2023Review
- White Matter and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.Neurology and therapy · 2022Article
- Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Magnetic Resonance Imaging in Tauopathy Animal Models.Frontiers in aging neuroscience · 2021Review
- Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET-MR.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
introductionAlzheimer's disease (AD) is the most common form of dementia, characterized primarily by abnormal aggregation of two proteins, tau and amyloid beta. We assessed tau pathology and white matter connectivity changes in subfields of the hippocampus simultaneously in vivo in AD.
methodsTwenty-four subjects were scanned using simultaneous time-of-flight
resultsWe observed extensive tau elevation in the entorhinal/perirhinal regions, intermediate tau elevation in cornu ammonis 1/subiculum, and an absence of tau elevation in the dentate gyrus, relative to controls. Diffusion tensor imaging showed parahippocampal gyral fractional anisotropy was lower in AD and mild cognitive impairment compared to controls and strongly correlated with early tau accumulation in the entorhinal and perirhinal cortices. DISCUSSION: This study demonstrates the potential for quantifiable patterns of
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