Evidence map›Paper›PMID 34337098›Full record

ArticleOpen forum infectious diseases2021

Female Genital Schistosomiasis and HIV-1 Incidence in Zambian Women: A Retrospective Cohort Study.

Amy S Sturt, Emily L Webb, Comfort R Phiri, Maina Mudenda, Joyce Mapani, Barry Kosloff, Maina Cheeba, Kwame Shanaube, Justin Bwalya, Eyrun F Kjetland and 8 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Impact ofTropical medicine and infectious disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 5 countries.

Amy S SturtDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0003-3437-3334
Emily L WebbMRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.ORCID https://orcid.org/0000-0002-4019-7456
Comfort R PhiriZambart, Lusaka, Zambia.
Maina MudendaDepartment of Obstetrics and Gynaecology, Livingstone Central Hospital, Livingstone, Zambia.
Joyce MapaniDepartment of Obstetrics and Gynaecology, Livingstone Central Hospital, Livingstone, Zambia.
Barry KosloffDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Maina CheebaZambart, Lusaka, Zambia.
Kwame ShanaubeZambart, Lusaka, Zambia.
Justin BwalyaZambart, Lusaka, Zambia.
Eyrun F KjetlandDepartment of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
Suzanna C FrancisMRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
Paul L A M CorstjensDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Govert J van DamDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Lisette van LieshoutDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Isaiah HansingoDepartment of Obstetrics and Gynaecology, Livingstone Central Hospital, Livingstone, Zambia.
Helen AylesDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Richard J HayesMRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.
Amaya L BustinduyDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
London School of Hygiene & Tropical Medicine · GBZambart · ZMLeiden University Medical Center · NLOslo University Hospital · NO

Funding

Medical Research Council MR/K012126/1Medical Research Council MR/N023692/1Medical Research Council MR/R010161/1
6 · The paper itself

Abstract

backgroundFemale genital schistosomiasis (FGS) has been associated with prevalent HIV-1. We estimated the incidence of HIV-1 infection in Zambian women with and without FGS.

methodsWomen (aged 18-31, nonpregnant, sexually active) were invited to participate in this study in January-August 2018 at the final follow-up of the HPTN 071 (PopART) Population Cohort. HIV-1-negative participants at enrollment (n = 492) were included in this analysis, with testing to confirm incident HIV-1 performed in HPTN 071 (PopART). The association of incident HIV-1 infection with FGS (

resultsIncident HIV-1 infections were observed in 4.1% (20/492) of participants. Women with FGS were twice as likely to seroconvert as women without FGS but with no statistical evidence for a difference (adjusted rate ratio, 2.16; 95% CI, 0.21-12.30;

conclusionsDespite higher HIV seroconversion rates in women with FGS, there was no statistical evidence of association, possibly due to low power. Further longitudinal studies should investigate this association in a setting with higher schistosomiasis endemicity.

Indexed as

female genital schistosomiasisHIV incidenceparasitePCRpolymerase chain reactionSchistosoma haematobium

Identifiers

PMID34337098
PMCPMC8320261
OpenAlexW3177177821

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.