Evidence map›Paper›PMID 34337084›Full record

ArticleJournal of immunology research2021

Predictive Significance of the Prognostic Nutritional Index (PNI) in Patients with Severe COVID-19.

Wei Wei, Xingyue Wu, Chaoyuan Jin, Tong Mu, Guorong Gu, Min Min, Sucheng Mu, Yi Han

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei WeiDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5029-6063
Xingyue WuDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-0355-3703
Chaoyuan JinDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7123-7935
Tong MuNanjing Sport Institute, Nanjing, China.ORCID https://orcid.org/0000-0003-1789-6221
Guorong GuDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7829-6727
Min MinDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-6577-5745
Sucheng MuDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-3068-4795
Yi HanDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-4863-1130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic nutritional index (PNI) has been reported to significantly correlate with poor survival and postoperative complications in patients with various diseases, but its relationship with mortality in COVID-19 patients has not been addressed.

methodA multicenter retrospective study involving patients with severe COVID-19 was conducted to investigate whether malnutrition and other clinical characteristics could be used to stratify the patients based on risk.

resultsA total of 395 patients were included in our study, with 236 patients in the training cohort, 59 patients in the internal validation cohort, and 100 patients in the external validation cohort. During hospitalization, 63/236 (26.69%) and 14/59 (23.73%) patients died in the training and validation cohorts, respectively. PNI had the strongest relationships with the neutrophil-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) level but was less strongly correlated with the CURB65, APACHE II, and SOFA scores. The baseline PNI score, platelet (PLT) count, LDH level, and PaO

conclusionThese findings have implications for predicting the risk of mortality in COVID-19 patients at the time of admission and provide the first direct evidence that a lower PNI is related to a worse prognosis in severe COVID-19 patients.

Indexed as

Nutrition AssessmentAgedBlood PlateletsChinaCohort StudiesCOVID-19FemaleHumansHydro-LyasesMaleMalnutritionMiddle AgedPredictive Value of TestsPrognosisQuinineRetrospective StudiesbiioquinolHydro-Lyaseslactate dehydrataseQuinine

Identifiers

PMID34337084
PMCPMC8279875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.