Evidence map›Paper›PMID 34336923›Full record

ArticleFrontiers in molecular biosciences2021

Impact of Weaning and Maternal Immune Activation on the Metabolism of Pigs.

Bruce R Southey, Courtni R Bolt, Haley E Rymut, Marissa R Keever, Alexander V Ulanov, Zhong Li, Laurie A Rund, Rodney W Johnson, Sandra L Rodriguez-Zas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Effects of fasting and inflammatory challenges on the swine hepatic metabolome.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bruce R SoutheyDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Courtni R BoltDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Haley E RymutDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Marissa R KeeverDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Alexander V UlanovRoy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Zhong LiRoy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Laurie A RundDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Rodney W JohnsonDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Sandra L Rodriguez-ZasDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
University of Illinois Urbana-Champaign · US

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
NIDA NIH HHS P30 DA018310
6 · The paper itself

Abstract

Weaning wields environmental, social, and nutritional stresses that are detectable in the blood metabolite levels of the offspring. Prenatal stress in the form of maternal immune activation (MIA) in response to infection, which is associated with health and behavior disorders, also elicits prolonged changes in blood and brain cytokine and metabolite levels of the offspring. The goal of this study was to investigate the effects of weaning and MIA on the offspring's liver function to advance the understanding of the impact of stressors on peripheral and central nervous systems, physiology, and health. Gas chromatography-mass spectrometry analysis was used to compare the level of hepatic metabolites from 22-day-old pigs (

Indexed as

gas chromatographyhepatic metabolomics stressmass spectrometrymaternal immune activationweaning

Identifiers

PMID34336923
PMCPMC8319725
OpenAlexW3185979025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.