Evidence map›Paper›PMID 34336825›Full record

ArticleFrontiers in cell and developmental biology2021

Knockdown of Circular RNA hsa_circ_PVT1 Inhibited Laryngeal Cancer Progression via Preventing wnt4/β-Catenin Signaling Pathway Activation.

Feng Yu, Ying Lin, Mao-Mao Ai, Guo-Jie Tan, Jia-Li Huang, Zi-Rou Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Emerging Roles of CircPVT1 in Cancer Progression.Current pharmaceutical biotechnology · 2025
    Review
  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Feng YuDepartment of Otolaryngology Head and Neck, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Ying LinDepartment of Otolaryngology Head and Neck, Guangzhou Twelfth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Mao-Mao AiDepartment of Otolaryngology Head and Neck, Guangzhou Twelfth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Guo-Jie TanDepartment of Otolaryngology Head and Neck, Guangzhou Twelfth People's Hospital, Guangzhou Medical University, Guangzhou, China.
Jia-Li HuangDepartment of Otolaryngology Head and Neck, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, China.
Zi-Rou ZouDepartment of Otolaryngology Head and Neck, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.
Guangzhou Medical University · CNJinan University · CNGuangdong Medical College · CNTwelfth Guangzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the function and mechanism of circular has_circ_PVT1 on laryngeal cancer (LC).

methodsMicroarray chip was performed to screen the differential expression of circRNA. Western blot and qRT-PCR was employed to detect the protein and mRNA level. CCK-8, clone formation, cell cycle, wound healing, and Transwell assay were performed to detect the cell proliferation, migration, and invasion ability. Luciferase assay and Fish were used to confirm the relationship between circ_PVT1/CBX4 and miR-21-5p. Flow cytometry and TUNEL assay were carried out to assess the apoptosis level.

resultsThe upregulation of circ_PVT1 was found in LC tissues and cells. Silencing of circ_PVT1 inhibited LC progression via targeting miR-21-5p and indirectly controlling CBX4. Wnt4/β-catenin signal pathway was inactivated by inhibiting the expression of circ_PVT1.

conclusionKnockdown of circ_PVT1 prevented LC progression via targeting miR-21-5p/CBX4 by inhibiting wnt4/β-catenin signal pathway, which could provide a novel therapeutic target for LC.

Indexed as

cell proliferationhas_circ_PVT1laryngeal cancermiR-21-5p/CBX4wnt4/β-catenin signal pathway

Identifiers

PMID34336825
PMCPMC8322683
OpenAlexW3183927101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.