Evidence map›Paper›PMID 34336805›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System.

Juyong Chung, Youngdo Jung, Shin Hur, Jin Ho Kim, Sung June Kim, Wan Doo Kim, Yun-Hoon Choung, Seung-Ha Oh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Juyong ChungDepartment of Otolaryngology, Wonkwang University School of Medicine, Iksan, South Korea.
Youngdo JungDepartment of Nature-Inspired System and Application, Korea Institute of Machinery and Materials, Daejeon, South Korea.
Shin HurDepartment of Nature-Inspired System and Application, Korea Institute of Machinery and Materials, Daejeon, South Korea.
Jin Ho KimNano-Bioelectronics & Systems Laboratory, Department of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea.
Sung June KimNano-Bioelectronics & Systems Laboratory, Department of Electrical and Computer Engineering, Seoul National University, Seoul, South Korea.
Wan Doo KimDepartment of Nature-Inspired System and Application, Korea Institute of Machinery and Materials, Daejeon, South Korea.
Yun-Hoon ChoungDepartment of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea.
Seung-Ha OhDepartment of Otorhinolaryngology, Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
Korea Institute of Machinery and Materials · KRSeoul National University · KRAjou University · KRWonkwang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analysis. To overcome these, artificial basilar membranes (ABMs) made of piezoelectric materials have been studied. This study aimed to verify the conceptual idea of a totally implantable ABM system. A prototype of the totally implantable system composed of the ABM developed in previous research, an electronic module (EM) for the amplification of electrical output from the ABM, and electrode was developed. We investigated the feasibility of the ABM system and obtained meaningful auditory brainstem responses of deafened guinea pigs by implanting the electrode of the ABM system. Also, an optimal method of coupling the ABM system to the human ossicle for transducing sound waves into electrical signals using the middle ear vibration was studied and the electrical signal output according to the sound stimuli was measured successfully. Although the overall power output from the ABM system is still less than the conventional CIs and further improvements to the ABM system are needed, we found a possibility of the developed ABM system as a totally implantable CIs in the future.

Indexed as

basilar membranebiomimeticscochlear implanthearing losssensorineural

Identifiers

PMID34336805
PMCPMC8324085
OpenAlexW3184092836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.