ReviewFrontiers in chemistry2021
Structural Flexibility in Metal-Organic Cages.
Review in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- A Multi-Stimuli Transformational Network of Benzil-Based Pd(II) Assemblies.Angewandte Chemie (International ed. in English) · 2026Article
- Programming Palladium Cage Geometry through Ligand Redox Modulation.Angewandte Chemie (International ed. in English) · 2026Article
- Peptide cages: bioinspired supramolecular architectures for next-generation applications.Chemical science · 2026Review
- Ligand Side-Chains Control the Formation of an MInorganic chemistry · 2026Article
- A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for DNA Three-Way Junctions by Induced Fit.Journal of the American Chemical Society · 2025Article
- A pseudo-cubic metal-organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation.Nature chemistry · 2025Article
- Functional Post-Synthetic Chemistry of Metal-Organic Cages According to Molecular Architecture and Specific Geometry of Origin.Molecules (Basel, Switzerland) · 2025Review
- Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages.Beilstein journal of organic chemistry · 2025Article
- Interplay of Stereochemistry and Charge Governs Guest Binding in Flexible ZnJournal of the American Chemical Society · 2024Article
- Structural Transformations of Metal-Organic Cages through Tetrazine-Alkene Reactivity.Journal of the American Chemical Society · 2024Article
- Coordination cages integrated into swelling poly(ionic liquid)s for guest encapsulation and separation.Nature communications · 2024Article
- Diastereoselective Self-Assembly of Low-Symmetry PdAngewandte Chemie (International ed. in English) · 2023Article
- Systematic exploration of accessible topologies of cage moleculesChemical science · 2023Article
- Guest Encapsulation Alters the Thermodynamic Landscape of a Coordination Host.Journal of the American Chemical Society · 2023Article
- A Diverse Array of Large Capsules Transform in Response to Stimuli.Journal of the American Chemical Society · 2023Article
- Allosterically Regulated Guest Binding Determines Framework Symmetry for an FeAngewandte Chemie (International ed. in English) · 2023Article
- Maximized axial helicity in a PdChemical science · 2023Article
- Roles of Metal Ions in Foldamers and Other Conformationally Flexible Supramolecular Systems.ACS organic & inorganic Au · 2022Review
- Pseudo-heterolepticity in Low-Symmetry Metal-Organic Cages.Angewandte Chemie (International ed. in English) · 2022Article
- Hydrogen Isotope Separation Using a Metal-Organic Cage Built from Macrocycles.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-organic cages (MOCs) have emerged as a diverse class of molecular hosts with potential utility across a vast spectrum of applications. With advances in single-crystal X-ray diffraction and economic methods of computational structure optimisation, cavity sizes can be readily determined. In combination with a chemist's intuition, educated guesses about the likelihood of particular guests being bound within these porous structures can be made. Whilst practically very useful, simple rules-of-thumb, such as Rebek's 55% rule, fail to take into account structural flexibility inherent to MOCs that can allow hosts to significantly adapt their internal cavity. An often unappreciated facet of MOC structures is that, even though relatively rigid building blocks may be employed, conformational freedom can enable large structural changes. If it could be exploited, this flexibility might lead to behavior analogous to the induced-fit of substrates within the active sites of enzymes. To this end, in-roads have already been made to prepare MOCs incorporating ligands with large degrees of conformational freedom. Whilst this may make the constitution of MOCs harder to predict, it has the potential to lead to highly sophisticated and functional synthetic hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.