Evidence map›Paper›PMID 34336745›Full record

ArticleFrontiers in pediatrics2021

Case Report: Two Distinct Focal Congenital Hyperinsulinism Lesions Resulting From Separate Genetic Events.

Elizabeth Rosenfeld, Lauren Mitteer, Kara Boodhansingh, Susan A Becker, Heather McKnight, Linda Boyajian, Amanda M Ackermann, Jennifer M Kalish, Tricia R Bhatti, Lisa J States and 3 more

Registry-linked trialOpen access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01916148 (Expanded Access Use of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01916148 availablenot on this map

Expanded Access Use of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

Typeexpanded_accessSponsorChildren's Hospital of PhiladelphiaConditionsCongenital Hyperinsulinism (CHI), Beckwith-Wiedemann Syndrome, InsulinomaArms18F-DOPA
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Congenital Hyperinsulinism With Paternally InheritedJournal of the ASEAN Federation of Endocrine Societies · 2026
    Article
  2. Article
  3. Approach to the Neonate With Hypoglycemia.The Journal of clinical endocrinology and metabolism · 2024
    Review
  4. Review
  5. Congenital Hyperinsulinism Caused by Mutations inInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Review
  8. Functional Regulation of KFrontiers in pharmacology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Elizabeth RosenfeldDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Lauren MitteerDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Kara BoodhansinghDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Susan A BeckerDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Heather McKnightDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Linda BoyajianDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Amanda M AckermannDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Jennifer M KalishCongenital Hyperinsulinism Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Tricia R BhattiCongenital Hyperinsulinism Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Lisa J StatesCongenital Hyperinsulinism Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
N Scott AdzickCongenital Hyperinsulinism Center, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Katherine LordDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Diva D De LeónDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Insulin Secretion in Hyperinsulinism Human IsletsR01DK098517 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI DE LEON, DIVA D. · 2013 to 2023
$4.5M
NIDDK NIH HHS R01 DK098517
6 · The paper itself

Abstract

Focal hyperinsulinism (HI) comprises nearly 50% of all surgically treated HI cases and is cured if the focal lesion can be completely resected. Pre-operative localization of the lesion is thus critical. Few cases of hyperinsulinism with multiple focal lesions have been reported, and assessment of the molecular mechanisms driving this rare occurrence has been limited. We present two cases of multifocal HI, each resulting from two independent, pancreatic focal lesions.

Indexed as

beta cellscase reporthypoglycemiaisletsKATP channelpancreas

Identifiers

PMID34336745
PMCPMC8322518
OpenAlexW3183195938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.