Evidence map›Paper›PMID 34336629›Full record

ArticleAnesthesiology and pain medicine2021

COVID-19 Related Acro-Ischemic Neuropathic-like Painful Lesions in Pediatric Patients: A Case Series.

Alfonso Papa, Anna Maria Salzano, Maria Teresa Di Dato, Giuliano Lo Bianco, Mariangela Tedesco, Antonio Salzano, Dariusz Myrcik, Farnad Imani, Giustino Varrassi, Ghodrat Akhavan Akbari and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  6. What role of the cGAS-STING pathway plays in chronic pain?Frontiers in molecular neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Alfonso PapaPain Department, AO "Ospedali dei Colli". Monaldi Hospital, Naples, Italy.
Anna Maria SalzanoPain Department, AO "Ospedali dei Colli". Monaldi Hospital, Naples, Italy.
Maria Teresa Di DatoPain Department, AO "Ospedali dei Colli". Monaldi Hospital, Naples, Italy.
Giuliano Lo BiancoDepartment of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Catania, Italy.
Mariangela TedescoPediatric Department, ASL NA2 North, Naples, Italy.
Antonio SalzanoEmergency Department, Frattamaggiore Hospital, Naples, Italy.
Dariusz MyrcikEmergency Med. Dept of Internal Medicine, University of Silesia in Katowice, Bytom, Poland.
Farnad ImaniPain Research Center, Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0003-0814-0772
Giustino VarrassiPaolo Procacci Foundation, Rome, Italy.ORCID https://orcid.org/0000-0002-3822-2923
Ghodrat Akhavan AkbariDepartment of Anesthesiology, Ardabil University of Medical Sciences, Ardabil, Iran.
Antonella PaladiniDepartment of MESVA, University of L'Aquila, L'Aquila, Italy.ORCID https://orcid.org/0000-0002-1219-9315
Ospedale Monaldi · ITArdabil University of Medical Sciences · IRBasildon and Thurrock University Hospitals NHS Foundation Trust · GBFondazione Roma · ITIran University of Medical Sciences · IRUniversity of L'Aquila · ITUniversity of Silesia in Katowice · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA variety of skin manifestations have been associated with COVID-19 infection. Acral lesions on hands and feet, closely resembling chilblains, have been reported in association with COVID-19, which are nonspecific. These acro-ischemic painful lesions have been described mainly in asymptomatic and mildly symptomatic pediatric COVID-19 positive patients, without a precise pathogenetic mechanism. COVID-19-induced chilblains may portend an indolent course and a good outcome. In young patients, the IFN-1 response induces microangiopathic changes and produces a chilblain lupus erythematosus-like eruption with vasculitic neuropathic pain features.

objectivesThis paper presented a case series of pediatric patients with COVID-19-related skin lesions and neuropathic-like pain.

methodsClinical outcomes were collected from 11 patients diagnosed with painful erythematous skin lesions with neuropathic-like pain and positive IgG for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

resultsIt is a mildly symptomatic condition not related to severe pain rates, and it is treated with paracetamol due to the transitory nature of the problem, which provides good results.

conclusionsA particular point of interest is skin lesion manifestation as a further indirect sign of SARS-CoV-2 infection. Due to the initial manifestation of chilblains in pauci-symptomatic pediatric patients, they need to be immediately tested and isolated. Chilblains can be considered a clinical clue to suspect SARS-CoV-2 infection and help in early diagnosis, patient triage, and infection control.

Indexed as

Child, VasculitisCoronavirusCOVID-19Neuropathic-like Pain

Identifiers

PMID34336629
PMCPMC8314085
OpenAlexW3153037243

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.