Evidence map›Paper›PMID 34336097›Full record

ArticleOxidative medicine and cellular longevity2021

Adiponectin Treatment Attenuates Cerebral Ischemia-Reperfusion Injury through HIF-1

Chan Zhang, Luming Zhen, Zongping Fang, Liang Yu, Yuanyuan Zhang, Haidong Wei, Junfeng Jia, Shiquan Wang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chan ZhangOutpatient Department, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Luming ZhenDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
Zongping FangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Liang YuDepartment of Information, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Yuanyuan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
Haidong WeiDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710032, China.
Junfeng JiaDepartment of Immunology, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.ORCID https://orcid.org/0000-0003-2764-970X
Shiquan WangDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.ORCID https://orcid.org/0000-0002-9946-1880
Second Affiliated Hospital of Xi'an Jiaotong University · CNXijing Hospital · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adiponectin (ADPN) plays an important role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that ADPN pretreatment has a protective effect on ischemic stroke, the therapeutic effect of ADPN on ischemic stroke and the underlying mechanism are still unclear. In order to clarify these questions, focal transient cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in mice and ADPN was administered for three times at 6 h, 24 h, and 48 h after reperfusion. Meanwhile, a virus-delivered HIF-1

Indexed as

AdiponectinAnimalsAntioxidantsBrain IschemiaDisease Models, AnimalHypoxia-Inducible Factor 1, alpha SubunitMaleMiceReperfusion InjuryTransfectionAdiponectinAntioxidantsHif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID34336097
PMCPMC8298180
OpenAlexW3178491835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.