Evidence map›Paper›PMID 34335964›Full record

ArticleTheranostics2021

Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer.

Meng-Jen Wu, Chih-Jung Chen, Ting-Yu Lin, Ying-Yuan Liu, Lin-Lu Tseng, Mei-Ling Cheng, Chih-Pin Chuu, Huai-Kuang Tsai, Wen-Ling Kuo, Hsing-Jien Kung and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
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  14. Role of ENO1 and its targeted therapy in tumors.Journal of translational medicine · 2024
    Review
  15. Review
  16. USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Review
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Meng-Jen WuInstitute of Molecular and Cellular Biology and Department of Life Science, National Tsing-Hua University, Hsinchu 30013, Taiwan.
Chih-Jung ChenDepartment of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Ting-Yu LinInstitute of Molecular and Cellular Biology and Department of Life Science, National Tsing-Hua University, Hsinchu 30013, Taiwan.
Ying-Yuan LiuInstitute of Molecular and Cellular Biology and Department of Life Science, National Tsing-Hua University, Hsinchu 30013, Taiwan.
Lin-Lu TsengInstitute of Molecular and Cellular Biology and Department of Life Science, National Tsing-Hua University, Hsinchu 30013, Taiwan.
Mei-Ling ChengDepartment of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chih-Pin ChuuInstitute of Cellular and System Medicine, National Health Research Institutes, Miaoli 35053, Taiwan.
Huai-Kuang TsaiInstitute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.
Wen-Ling KuoDivision of Breast Surgery, General Surgery, Department of Surgery, Chang Gung Memorial Hospital Linko Medical Center, Taoyuan 333, Taiwan.
Hsing-Jien KungGraduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei 110, Taiwan.
Wen-Ching WangInstitute of Molecular and Cellular Biology and Department of Life Science, National Tsing-Hua University, Hsinchu 30013, Taiwan.
Chang Gung University · TWChung Shan Medical University · TWInstitute of Information Science, Academia Sinica · TWNational Health Research Institutes · TWUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Androgen AntagonistsAnimalsCell Line, TumorCell ProliferationGene ExpressionGene Expression Regulation, NeoplasticHeterograftsHumansJumonji Domain-Containing Histone DemethylasesMaleMiceMice, Inbred BALB CProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantReceptors, AndrogenSignal TransductionAndrogen AntagonistsJumonji Domain-Containing Histone DemethylasesKDM4B protein, humanReceptors, AndrogenTranscription FactorsCastration-resistant prostate cancerc-Mychistone demethylaseKDM4Bmetabolic rewiring

Identifiers

PMID34335964
PMCPMC8315051
OpenAlexW3184466940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.