Evidence map›Paper›PMID 34335961›Full record

ArticleTheranostics2021

Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways.

Alexander Zheleznyak, Matthew Mixdorf, Lynne Marsala, Julie Prior, Xiaoxia Yang, Grace Cui, Baogang Xu, Steven Fletcher, Francesca Fontana, Gregory Lanza and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alexander ZheleznyakDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew MixdorfDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lynne MarsalaDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Julie PriorDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Xiaoxia YangDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Grace CuiDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Baogang XuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Steven FletcherDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Francesca FontanaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gregory LanzaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Samuel AchilefuDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USUniversity of Maryland, Baltimore · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M · 2015 to 2019
$11.5M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPYR01CA260855 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2021 to 2025
$3.5M
OVERCOMING THE PROTECTIVE BARRIERS OF BREAST CANCER IN BONE MARROW WITH TARGETED PRODRUG NANOTHERAPYR01CA216840 · NCI · WASHINGTON UNIVERSITY · PI LANZA, GREGORY M, WEILBAECHER, KATHERINE NELSON · 2018 to 2022
$3.1M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
Imaging Goggles for Fluorescence-Guided SurgeryR01EB030987 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL, BURAS, WILLIAM ROBINSON · 2021 to 2024
$2.1M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEMS10OD016237 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2014 to 2014
$267k
IVIS LUMINA II XR FOR OPTICAL IMAGING OF RADIOPHARMACEUTICALSS10RR031625 · NCRR · WASHINGTON UNIVERSITY · PI TAI, YUAN-CHUAN · 2011 to 2011
$218k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA216840NCI NIH HHS R01 CA260855NCI NIH HHS U54 CA199092NCRR NIH HHS S10 RR031625NIAMS NIH HHS P30 AR074992NIBIB NIH HHS R01 EB021048NIBIB NIH HHS R01 EB030987NIH HHS S10 OD016237NIH HHS S10 OD020129NIH HHS S10 OD027042
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsApoptosisBone and BonesBone MarrowBone NeoplasmsCell DeathCell Line, TumorFluorodeoxyglucose F18HumansIntegrin alpha ChainsMiceMultiple MyelomaOrganometallic CompoundsOsteoclastsOsteolysisRadioisotopesCDw49dFluorodeoxyglucose F18Integrin alpha ChainsOrganometallic CompoundsRadioisotopesRadiopharmaceuticalsReactive Oxygen Speciestitanocenebone marrowCerenkov radiationmultiple myelomananomicellesorthogonal drug deliveryphotosensitizertumor microenvironment

Identifiers

PMID34335961
PMCPMC8315072
OpenAlexW3185679699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.