Evidence map›Paper›PMID 34335960›Full record

ArticleTheranostics2021

Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice.

Jyotirmaya Behera, Anil Kumar, Michael J Voor, Neetu Tyagi

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  18. Roles of skeletal muscle-derived exosomes in osteoporosis.Journal of translational medicine · 2025
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jyotirmaya BeheraBone Biology Laboratory, Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Anil KumarJames Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, KY 40202, USA.
Michael J VoorDepartments of Orthopaedic Surgery and Bioengineering, School of Medicine and Speed School of Engineering, University of Louisville, Louisville, KY 40202, USA.
Neetu TyagiBone Biology Laboratory, Department of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · US

Funding

Mitigating mitochondrial epigenetics in bone remodeling by hydrogen sulfideR01AR067667 · NIAMS · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU, TYAGI, SURESH C. · 2015 to 2019
$2.5M
Exosomal Delivery of TFAM:Novel Therapeutic Approach to Cardiomyocyte Recovery in Heart FailureF31HL132527 · NHLBI · UNIVERSITY OF LOUISVILLE · PI KUNKEL, GEORGE H. · 2016 to 2016
$30k
NHLBI NIH HHS F31 HL132527NIAMS NIH HHS R01 AR067667
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiopoietin-1AnimalsBone and BonesCell Line, TumorEndothelial CellsExosomesGenes, Tumor SuppressorMesenchymal Stem CellsMiceMicroRNAsNeovascularization, PathologicNitric OxideOsteogenesisReceptor, TIE-2RNA, Long NoncodingSignal TransductionAngiopoietin-1Angpt1 protein, mouseH19 long non-coding RNAMicroRNAsMirn106 microRNA, mouseNitric OxideReceptor, TIE-2RNA, Long NoncodingTek protein, mouseAngiogenesisBone formationExtracellular vesicleslncRNA-H19 regulationmiRNA sponge

Identifiers

PMID34335960
PMCPMC8315071
OpenAlexW3184885059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.