ArticleEvidence-based complementary and alternative medicine : eCAM2021
Effect of Yiqi Huoxue Granules on Platelet Activation Induced by Thrombin.
Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
objectiveTo study the effects of Yiqi Huoxue (YQHX) granules on platelet activation and aggregation induced by thrombin.
methodsThe effect of YQHX on platelet aggregation rate was detected by platelet aggregation instrument; the effect of YQHX on thrombosis time was observed by the mouse mesentery thrombosis model. DAMI cells were induced to transform into platelet-like granules using PMA, and the effects of SCH (PAR-1 inhibitor) on thrombin-induced changes in platelet intracellular calcium concentration, PAR-1 protein expression, and phosphorylation of MAPK were examined.
resultsCompared with the control group, the platelet aggregation rate, PAR-1 protein expression, phosphorylation of ERK1/2, and p38 protein in the YQHX group decreased (
conclusionYQHX suppresses the platelet activation induced by thrombin by inhibiting PAR-1 expression.
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