Evidence map›Paper›PMID 34335826›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Sihem Berdja, Lynda Boudarene, Leila Smail, Samia Neggazi, Saliha Boumaza, Abdelhamid Sahraoui, El-Mehdi Haffaf, Ghouti Kacimi, Souhila Aouichat Bouguerra

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Golden thistle (Food science & nutrition · 2023
    Article
  2. Quality and Safety of Ready-to-Eat Golden Thistle (Plants (Basel, Switzerland) · 2023
    Article
  3. Comparative Research on Intestinal Functions of Wild and CulturedAnimals : an open access journal from MDPI · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sihem BerdjaLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.ORCID https://orcid.org/0000-0001-6780-7165
Lynda BoudareneLaboratory of Organic and Functionally Analysis, Faculty of Chemistry, USTHB, Algiers, Algeria.
Leila SmailLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.
Samia NeggaziLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.
Saliha BoumazaLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.
Abdelhamid SahraouiLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.
El-Mehdi HaffafLaboratory of Nuclear Medicine of Central Hospital of Army, Algiers, Algeria.
Ghouti KacimiLaboratory of Biochemistry of Central Hospital of Army, Algiers, Algeria.
Souhila Aouichat BouguerraLaboratory of Cellular and Molecular Physiopathology, Faculty of Biological Sciences, University of Science and Technology Houari Boumediene, BP 32 DZ-16011 El Allia, Algiers, Algeria.
University of Sciences and Technology Houari Boumediene · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLipotoxicity is characterized by a metabolic disturbance leading to the development of nonalcoholic fatty liver disease (NAFLD). Some medicinal plant extracts exert hepatoprotective activity by modulating oxidative stress, inflammation, and metabolic disorders.

objectiveIn this study, we aimed to determine the effects of MATERIALS AND

methodsOur experiment focused on the administration of an HFD (40%) in

resultsLipotoxicity induced metabolic disorders, both serum and tissue. HFD induced an increase in the total lipids and a decrease in glycogen reserve and an alteration in the oxidant-antioxidant balance. HFD induced an increase in markers of liver damage, which resulted in NAFLD, confirmed by histological study and hepatocytes cell culture.

conclusionGolden thistle improves glucose tolerance and hyperlipidemia and ameliorates hepatic steatosis by reducing oxidative stress, inflammation, and lipid accumulation. Its incorporation into a dietary program or as an aliment supplement would prevent hepatic complications associated with an HFD.

Identifiers

PMID34335826
PMCPMC8289590
OpenAlexW3182585758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.