Evidence map›Paper›PMID 34335772›Full record

ReviewInternational journal of dentistry2021

Genetic Aspects of Dental Erosive Wear and Dental Caries.

Amela Tulek, Aida Mulic, Maria Runningen, Jannike Lillemo, Tor Paaske Utheim, Qalbi Khan, Amer Sehic

Abstract readReview
In one paragraph

Review in International journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Integrative Analysis ofDentistry journal · 2026
    Article
  3. Article
  4. Prevalence and related risk factors of erosive tooth wear in Chilean schoolchildren. A cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amela TulekDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-8976-6226
Aida MulicNordic Institute of Dental Materials (NIOM), Oslo, Norway.ORCID https://orcid.org/0000-0002-3784-7278
Maria RunningenDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Jannike LillemoDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Tor Paaske UtheimDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-3821-6777
Qalbi KhanDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
Amer SehicDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0001-8203-5511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe present review aims to give an overview of the literature focusing on novel genetic aspects of dental erosion and dental caries. Once the tooth erupts into the oral cavity, the regenerative capability of enamel is fundamentally limited due to the loss of dental epithelium during eruption. The susceptibility or resistance to dental erosion and caries is presumably a result of environmental, phenotypic, and/or genetic influence. Even though it is evident that individuals frequently exposing their teeth to acid and sugar are at high risk of developing dental erosion and caries, the findings exclusively based on these factors are elusive.

conclusionThe high prevalence of erosion and caries among certain groups, and observations that not all individuals appearing to be at risk develop these lesions, has sparked research on identifying genetic effects to these conditions. A connection of genome-wide and candidate gene studies has increased considerably in the literature. This review reveals largely varying success among studies, demonstrating the difficulties of developing the study with adequate sample sizes and durable phenotype definitions that permit enough statistical power to identify genetic contributors.

Identifiers

PMID34335772
PMCPMC8292068

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.