Evidence map›Paper›PMID 34335680›Full record

ArticleFrontiers in genetics2021

Interaction of HLA Class II rs9272219 and

Sandra Rosas-Madrigal, María Teresa Villarreal-Molina, José Flores-Rivera, Verónica Rivas-Alonso, Luis Rodrigo Macias-Kauffer, Graciela Ordoñez, María Del Carmen Chima-Galán, Víctor Acuña-Alonzo, Gastón Macín-Pérez, Rodrigo Barquera and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Sandra Rosas-MadrigalLaboratorio de Enfermedades Mendelianas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
María Teresa Villarreal-MolinaLaboratorio de Genómica de Enfermedades Cardiovasculares, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
José Flores-RiveraLaboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" (INNN), Mexico City, Mexico.
Verónica Rivas-AlonsoLaboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" (INNN), Mexico City, Mexico.
Luis Rodrigo Macias-KaufferUnidad de Genómica de Poblaciones Aplicada a La Salud, Facultad de Química, UNAM/INMEGEN, Mexico City, Mexico.
Graciela OrdoñezLaboratorio de Neuroinmunología, INNN, Mexico City, Mexico.
María Del Carmen Chima-GalánDivisión de Medicina Genómica, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City, Mexico.
Víctor Acuña-AlonzoEscuela Nacional de Antropología e Historia, Mexico City, Mexico.
Gastón Macín-PérezEscuela Nacional de Antropología e Historia, Mexico City, Mexico.
Rodrigo BarqueraDepartment of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, Germany.
Julio GranadosDepartamento de Trasplantes, Instituto Nacional de Ciencias Medicas y Nutrición "Salvador Zubirán", Mexico City, Mexico.
Ricardo Valle-RiosDivisión de Investigación, Facultad de Medicina, Unidad de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Teresa CoronaLaboratorio Clínico de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suarez" (INNN), Mexico City, Mexico.
Alessandra CarnevaleLaboratorio de Enfermedades Mendelianas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
Sandra Romero-HidalgoDepartamento de Genómica Computacional, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.
National Institute of Genomic Medicine · MXInstituto Nacional de Neurología y Neurocirugía · MXEscuela Nacional de Antropología e HistoriaHospital Infantil de México Federico Gómez · MXInstitute for Social Security and Services for State Workers · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXMax Planck Institute for the Science of Human History · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromyelitis Optica Spectrum Disorder (NMOSD) is a demyelinating autoimmune disease of the central nervous system, more prevalent in individuals of non-European ancestry. Few studies have analyzed genetic risk factors in NMOSD, and HLA class II gene variation has been associated NMOSD risk in various populations including Mexicans. Thymopoietin (

Indexed as

genetic interactionHLANMOSDrs17028450rs9272219TMPO

Identifiers

PMID34335680
PMCPMC8320513
OpenAlexW3186862313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.