Evidence map›Paper›PMID 34335620›Full record

ArticleFrontiers in immunology2021

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.

Pavlo Gilchuk, Adrian Guthals, Stefano R Bonissone, Jared B Shaw, Philipp A Ilinykh, Kai Huang, Robin G Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson and 9 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Pavlo GilchukThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Adrian GuthalsMapp Biopharmaceutical, Inc. San Diego, CA, United States.
Stefano R BonissoneAbterra Biosciences (formerly Digital Proteomics LLC), San Diego, CA, United States.
Jared B ShawEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, United States.
Philipp A IlinykhDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Kai HuangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Robin G BombardiThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Jenny LiangIntegral Molecular, Inc., Philadelphia, PA, United States.
Ariadna GrinyoIntegral Molecular, Inc., Philadelphia, PA, United States.
Edgar DavidsonIntegral Molecular, Inc., Philadelphia, PA, United States.
Elaine C ChenDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Bronwyn M GunnRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, United States.
Erica Ollmann SaphireCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.
Benjamin J DoranzIntegral Molecular, Inc., Philadelphia, PA, United States.
Alexander BukreyevDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Larry ZeitlinMapp Biopharmaceutical, Inc. San Diego, CA, United States.
Natalie CastellanaAbterra Biosciences (formerly Digital Proteomics LLC), San Diego, CA, United States.
James E CroweThe Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

Regulatory Compliance Core - Galveston National Laboratory BSL4 OperationsUC7AI094660 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Gene Garrard Olinger · 2011 to 2026
$208.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Research Project 3: siRNA Therapy and Small Molecule Combination Treatment for FilovirusesU19AI142785 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GEISBERT, THOMAS WILLIAM · 2019 to 2023
$35.5M
Supplemental Research Project (SRP)U19AI109711 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GEISBERT, THOMAS WILLIAM · 2014 to 2018
$26.6M
Immunological Mechanisms of Disease Training ProgramT32AI138932 · NIAID · VANDERBILT UNIVERSITY · PI MAJOR, AMY S, RATHMELL, JEFFREY C. · 2019 to 2023
$1.4M
An integrated transcriptomic and proteomic approach to antibody sequencing and repertoire characterizationR44GM122102 · NIGMS · DIGITAL PROTEOMICS LLC · PI CASTELLANA, NATALIE · 2017 to 2018
$887k
Direct sequencing of serum antibodies after infectionR43AI129082 · NIAID · MAPP BIOPHARMACEUTICAL, INC. · PI GUTHALS, ADRIAN · 2017 to 2017
$255k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS UL1 RR024975NIAID NIH HHS HHSN272201400058CNIAID NIH HHS R43 AI129082NIAID NIH HHS T32 AI138932NIAID NIH HHS U19 AI109711NIAID NIH HHS U19 AI142785NIAID NIH HHS UC7 AI094660NIGMS NIH HHS R44 GM122102
6 · The paper itself

Abstract

Three clinically relevant ebolaviruses - Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa. The largest Ebola virus disease (EVD) epidemic to date in 2013-2016 in West Africa highlighted the urgent need for countermeasures, leading to the development and FDA approval of the Ebola virus vaccine rVSV-ZEBOV (Ervebo

Indexed as

AdultAntibodies, NeutralizingAntibodies, ViralAntigens, ViralEbolavirusHemorrhagic Fever, EbolaHumansMaleMembrane GlycoproteinsProteomicsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralMembrane Glycoproteinsconvalescent plasmaebolavirusebolavirus infectionepitope mappingglycoproteinneutralizing antibodiesproteo-genomicsviral antibodies

Identifiers

PMID34335620
PMCPMC8322977

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.