Evidence map›Paper›PMID 34335597›Full record

ArticleFrontiers in immunology2021

Ancient DNA Study in Medieval Europeans Shows an Association Between HLA-DRB1*03 and Paratyphoid Fever.

Magdalena Haller, Joanna H Bonczarowska, Dirk Rieger, Tobias L Lenz, Almut Nebel, Ben Krause-Kyora

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Ancient DNA and Human Physiology.Physiology (Bethesda, Md.) · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Magdalena HallerInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Joanna H BonczarowskaInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Dirk RiegerDepartment of Archaeology, Hanseatic City of Lübeck Historic Monuments Protection Authority, Lübeck, Germany.
Tobias L LenzResearch Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Ben Krause-KyoraInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Kiel University · DEMax Planck Institute for Evolutionary Biology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Outbreaks of infectious diseases repeatedly affected medieval Europe, leaving behind a large number of dead often inhumed in mass graves. Human remains interred in two burial pits from 14

Indexed as

DNA, AncientGenetic Predisposition to DiseaseGermanyHLA-DRB1 ChainsHumansParatyphoid FeverWhite PeopleDNA, AncientHLA-DRB1 Chainsantigen binding predictionenteric feverhuman leukocyte antigenSalmonella enterica Paratyphi Ctrade-off

Identifiers

PMID34335597
PMCPMC8320744
OpenAlexW3183157201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.