ArticleFrontiers in microbiology2021
Effect of a Multispecies Probiotic Mixture on the Growth and Incidence of Diarrhea, Immune Function, and Fecal Microbiota of Pre-weaning Dairy Calves.
Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial.Nature communications · 2024Trial
- Sheep-derived probiotics alleviate weaning-induced oxidative stress in lambs via the gut-liver axis.NPJ biofilms and microbiomes · 2026Article
- Composite probiotics improve growth performance and enhance immune and antioxidant capacity in weaned yaks by modulating rumen microbiota and their metabolites.BMC microbiology · 2026Article
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.Journal of animal science and biotechnology · 2026Review
- The current studies on the mechanisms of lactic acid bacteria as probiotics in the alleviate of bovine diseases: a review.Frontiers in cellular and infection microbiology · 2026Review
- Differential Age-Based Response Induced by a Commercial Probiotic Supplementation in Pastured Goats.Probiotics and antimicrobial proteins · 2025Article
- Effect of Multi-Species Probiotic Supplementation on Fecal Microbiota in Pre-Weaned Holstein Dairy Calves in California.Microorganisms · 2025Article
- Analysis of the Microbiota of Milk from Holstein-Friesian Dairy Cows Fed a Microbial Supplement.Animals : an open access journal from MDPI · 2025Article
- Effects ofAnimals : an open access journal from MDPI · 2025Article
- Age-stratified gut microbial changes in diarrheal calves: insights from 16S rRNA sequencing across early development.Frontiers in microbiology · 2025Article
- Effects ofAnimals : an open access journal from MDPI · 2024Article
- Intake of compound probiotics accelerates the construction of immune function and gut microbiome in Holstein calves.Microbiology spectrum · 2024Article
- Comparable Evaluation of Nutritional Benefits ofAnimals : an open access journal from MDPI · 2023Article
- Effects of the Oat Hay Feeding Method and Compound Probiotic Supplementation on the Growth, Antioxidant Capacity, Immunity, and Rumen Bacteria Community of Dairy Calves.Antioxidants (Basel, Switzerland) · 2023Article
- Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves.Scientific reports · 2023Article
- Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves.Scientific reports · 2023Article
- A meta-analysis on the effects of probiotics on the performance of pre-weaning dairy calves.Journal of animal science and biotechnology · 2023Article
- Modulating gastrointestinal microbiota to alleviate diarrhea in calves.Frontiers in microbiology · 2023Review
- Dietary Supplementation of Fruit fromAnimals : an open access journal from MDPI · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of different doses of a multispecies probiotic (MSP) mixture on growth performance, the incidence of diarrhea rate and immune function, and fecal microbial diversity and structure were evaluated in pre-weaning Holstein dairy calves at WK2, WK4, WK6, and WK8. Forty Chinese Holstein female newborn calves were randomly assigned to four treatments with 10 calves in each group, C (control group), T1 (0.5 g MSP/calf/day, T2 (1 g MSP/calf/day), and T3 (2 g MSP/calf/day) groups. The experimental period was 56 days. Feed intake and health scoring were recorded every day until the end of the experiment. Fecal contents and blood samples were sampled at WK2, WK4, WK6, and WK8. Growth performance, incidence of diarrhea, and total serum concentrations (IgA, IgG, and IgM) were analyzed. Bacterial 16S rRNA and fungal ITS genes were high-throughput sequenced for fecal microbiota. The relationships among the populations of the principal fecal microbiota at WK2 and the growth performance or serum immunoglobulin concentrations were analyzed using Pearson's rank correlation coefficients. The MSP supplementation reduced the incidence of diarrhea in the first 4 weeks of life, and serum IgA, IgG, and IgM concentrations increased between WK2 and WK8 in the T3 group. There was an increase in growth performance and reduction in the incidence of diarrhea until WK4 after birth in T3 group, compared with the control, T1, and T2 groups. The results of fecal microbiota analysis showed that
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.