Evidence map›Paper›PMID 34335469›Full record

ArticleFrontiers in endocrinology2021

Calcium Ionophore (A23187) Rescues the Activation of Unfertilized Oocytes After Intracytoplasmic Sperm Injection and Chromosome Analysis of Blastocyst After Activation.

Ziwen Xu, Guidong Yao, Wenbin Niu, Huiying Fan, Xueshan Ma, Senlin Shi, Haixia Jin, Wenyan Song, Yingpu Sun

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Mitochondrial CaFrontiers in cell and developmental biology · 2026
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  15. Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ziwen XuCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Guidong YaoCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenbin NiuCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huiying FanCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xueshan MaCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Senlin ShiCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haixia JinCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenyan SongCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yingpu SunCenter for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium is a crucial factor in regulating the biological behavior of cells. The imbalance of calcium homeostasis in cytoplasm will cause abnormal behavior of cells and the occurrence of diseases. In intracytoplasmic sperm injection (ICSI) cycle, the dysfunction of oocyte activation caused by insufficient release of Ca

Indexed as

AneuploidyBlastocystCalcimycinCalcium IonophoresChromosomesEmbryonic DevelopmentFemaleHumansOocytesSperm Injections, IntracytoplasmicCalcimycinCalcium Ionophoresartificial oocyte activation (AOA)assisted reproductive technology (ART)calcium ionophore (A23187)fertilization failureintracytoplasmic sperm injection (ICSI)

Identifiers

PMID34335469
PMCPMC8320372
OpenAlexW3185639323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.