Evidence map›Paper›PMID 34335449›Full record

ArticleFrontiers in neurology2021

Cerebral Hemodynamic Correlates of Transcutaneous Auricular Vagal Nerve Stimulation in Consciousness Restoration: An Open-Label Pilot Study.

Yutian Yu, Yi Yang, Shuoqiu Gan, Shengnan Guo, Jiliang Fang, Shouyan Wang, Chunzhi Tang, Lijun Bai, Jianghong He, Peijing Rong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Yutian YuAcupuncture Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Yi YangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shuoqiu GanThe Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Shengnan GuoInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Jiliang FangDepartment of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Shouyan WangInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Chunzhi TangClinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Lijun BaiThe Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Jianghong HeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peijing RongInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
China Academy of Chinese Medical Sciences · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFudan University · CNGuangzhou University of Chinese Medicine · CNThe Military General Hospital of Beijing PLA · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to preliminarily illustrate the cerebral hemodynamic correlates of transcutaneous auricular vagal nerve stimulation (taVNS) in consciousness restoration. Arterial spin labeling (ASL) was adopted with functional magnetic resonance imaging (fMRI) to measure cerebral blood flow (CBF) changes before and after taVNS in 10 qualified patients with disorders of consciousness (DOC). Before taVNS, five patients responded to auditory stimuli (RtAS), and five did not respond to auditory stimuli (nRtAS). The RtAS DOC patients obtained favorable prognoses after the 4-week taVNS treatment, whereas the nRtAS ones did not. Simultaneously, taVNS increased CBF of multiple brain regions in the RtAS DOC patients, but hardly in the nRtAS ones. In conclusion, the preserved auditory function might be the prior key factor of the taVNS responders in DOC patients, and taVNS might alleviate RtAS DOC by activating the salience network, the limbic system, and the interoceptive system.

Indexed as

arterial spin labeling (ASL)cerebral blood flow (CBF)disorders of consciousness (DOC)functional magnetic resonance imaging (fMRI)non-responded to auditory stimuli (nRtAS)responded to auditory stimuli (RtAS)transcutaneous auricular vagal nerve stimulation (taVNS)

Identifiers

PMID34335449
PMCPMC8319239
OpenAlexW3183929315

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.