Evidence map›Paper›PMID 34335308›Full record

ArticleFrontiers in physiology2021

Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease.

Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuhl, Alzheimer's Disease Neuroimaging Initiative (ADNI)

Abstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amelie SchäferDepartment of Mechanical Engineering, Stanford University, Stanford, CA, United States.
Mathias PeirlinckDepartment of Mechanical Engineering, Stanford University, Stanford, CA, United States.
Kevin LinkaInstitute of Continuum and Materials Mechanics, Hamburg University of Technology, Hamburg, Germany.
Ellen KuhlDepartment of Mechanical Engineering, Stanford University, Stanford, CA, United States.
Alzheimer's Disease Neuroimaging Initiative (ADNI)

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Amyloid-β and hyperphosphorylated tau protein are known drivers of neuropathology in Alzheimer's disease. Tau in particular spreads in the brains of patients following a spatiotemporal pattern that is highly sterotypical and correlated with subsequent neurodegeneration. Novel medical imaging techniques can now visualize the distribution of tau in the brain

Indexed as

Alzheimer's diseaseBayesian inferencehierarchical modelingnetwork diffusion modeltau PETuncertainty quantification

Identifiers

PMID34335308
PMCPMC8322942

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.