ArticleFrontiers in physiology2021
Effects of Venoconstrictive Thigh Cuffs on Dry Immersion-Induced Ophthalmological Changes.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Understanding the relationship between intracranial pressure and spaceflight associated neuro-ocular syndrome (SANS): a systematic review.NPJ microgravity · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability.Frontiers in physiology · 2025Article
- Intraocular Pressure and Retinal Nerve Fiber Layer Changes in a Microgravity Mouse Model and Relevance to Spaceflight-Associated Neuro-Ocular Syndrome.Eye and brain · 2025Article
- Artificial gravity: an effective countermeasure for microgravity-induced headward fluid shift?Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Neuro-ophthalmological changes in healthy females exposed to a 5-day dry immersion: a pilot study.NPJ microgravity · 2024Article
- Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation.Nature communications · 2023Article
- Spaceflight associated neuro-ocular syndrome (SANS): an update on potential microgravity-based pathophysiology and mitigation development.Eye (London, England) · 2023Review
- Eye-brain axis in microgravity and its implications for Spaceflight Associated Neuro-ocular Syndrome.NPJ microgravity · 2023Review
- Spaceflight associated neuro-ocular syndrome: proposed pathogenesis, terrestrial analogues, and emerging countermeasures.The British journal of ophthalmology · 2023Review
- Head-mounted digital metamorphopsia suppression as a countermeasure for macular-related visual distortions for prolonged spaceflight missions and terrestrial health.Wearable technologies · 2022Article
- DI-5-Cuffs: Bone Remodelling and Associated Metabolism Markers in Humans After Five Days of Dry Immersion to Simulate Microgravity.Frontiers in physiology · 2022Article
- Early Deconditioning of Human Skeletal Muscles and the Effects of a Thigh Cuff Countermeasure.International journal of molecular sciences · 2021Article
- Reduced Regional Cerebral Blood Flow Measured byFrontiers in physiology · 2021Article
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuro-ophthalmological changes named spaceflight associated neuro-ocular syndrome (SANS) reported after spaceflights are important medical issues. Dry immersion (DI), an analog to microgravity, rapidly induces a centralization of body fluids, immobilization, and hypokinesia similar to that observed during spaceflight. The main objectives of the present study were 2-fold: (1) to assess the neuro-ophthalmological impact during 5 days of DI and (2) to determine the effects of venoconstrictive thigh cuffs (VTC), used as a countermeasure to limit headward fluid shift, on DI-induced ophthalmological adaptations. Eighteen healthy male subjects underwent 5 days of DI with or without VTC countermeasures. The subjects were randomly assigned into two groups of 9: a control and cuffs group. Retinal and optic nerve thickness were assessed with spectral-domain optical coherence tomography (OCT). Optic nerve sheath diameter (ONSD) was measured by ocular ultrasonography and used to assess indirect changes in intracranial pressure (ICP). Intraocular pressure (IOP) was assessed by applanation tonometry. A higher thickness of the retinal nerve fiber layer (RNFL) in the temporal quadrant was observed after DI. ONSD increased significantly during DI and remained higher during the recovery phase. IOP did not significantly change during and after DI. VTC tended to limit the ONSD enlargement but not the higher thickness of an RNFL induced by DI. These findings suggest that 5 days of DI induced significant ophthalmological changes. VTC were found to dampen the ONSD enlargement induced by DI.
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