Evidence map›Paper›PMID 34335296›Full record

ArticleFrontiers in physiology2021

Comparison Between 5- and 1-Year Outcomes Using Cutoff Values of Pressure Drop Coefficient and Fractional Flow Reserve for Diagnosing Coronary Artery Diseases.

Rupak K Banerjee, Sruthi Ramadurai, Shreyash M Manegaonkar, Marepalli B Rao, Sathyaprabha Rakkimuthu, Mohamed A Effat

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01719016 (Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01719016 active not recruitingnot on this map

Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics

TypeobservationalSponsorUniversity of CincinnatiRan2010 to 2026Enrolled68ConditionsCoronary Artery DiseaseArmsCardiac PET, Coronary catheterization
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rupak K BanerjeeDepartment of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, United States.
Sruthi RamaduraiDepartment of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, United States.
Shreyash M ManegaonkarDepartment of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, United States.
Marepalli B RaoDepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, United States.
Sathyaprabha RakkimuthuDepartment of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH, United States.
Mohamed A EffatDepartment of Cardiology, University of Cincinnati Medical Center, Cincinnati, OH, United States.
University of Cincinnati · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current pressure-based coronary diagnostic index, fractional flow reserve (FFR), has a limited efficacy in the presence of microvascular disease (MVD). To overcome the limitations of FFR, the objective is to assess the recently introduced pressure drop coefficient (CDP), a fundamental fluid dynamics-based combined pressure-flow index.

methodsWe hypothesize that CDP will result in improved clinical outcomes in comparison to FFR. To test the hypothesis, chi-square test was performed to compare the percent major adverse cardiac events (%MACE) at 5 years between (a) FFR < 0.75 and CDP > 27.9 and (b) FFR < 0.80 and CDP > 25.4 groups using a prospective cohort study. Furthermore, Kaplan-Meier survival curves were compared between the FFR and CDP groups. The results were considered statistically significant for

resultsFor the complete patient group, the %MACE in the CDP > 27.9 group (10 out of 35, 29%) was lower in comparison to the FFR < 0.75 group (11 out of 20, 55%), and the difference was near significant (

conclusionBased on the MACE and survival analysis outcomes, CDP could possibly be an alternate diagnostic index for decision-making in the cardiac catheterization laboratory. CLINICAL

trial registrationwww.ClinicalTrials.gov, identifier NCT01719016.

Indexed as

fractional flow reserve (FFR)intermediate coronary stenosisinterventional cardiologyMACEmicrovascular diseasespressure drop coefficient (CDP)survival analysis

Identifiers

PMID34335296
PMCPMC8317064
OpenAlexW3180902059

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.