Evidence map›Paper›PMID 34335277›Full record

ReviewFrontiers in pharmacology2021

The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review.

Jia-Hao Li, Jia-Li Liu, Kai-Kai Zhang, Li-Jian Chen, Jing-Tao Xu, Xiao-Li Xie

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Frontiers in pharmacology · 2026
    Article
  7. Mechanisms underlying methamphetamine-induced disruption of testicular integrity.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Substance use and use disorders during pregnancy and the postpartum period.American journal of obstetrics and gynecology · 2025
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jia-Hao LiDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Jia-Li LiuDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Kai-Kai ZhangDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Li-Jian ChenDepartment of Forensic Pathology, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Jing-Tao XuDepartment of Forensic Clinical Medicine, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Xiao-Li XieDepartment of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China.
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ toxicity in adults, including neurotoxicity, cardiovascular toxicity, and hepatotoxicity. It can also cross the placental barrier and have long-lasting effects on the fetus. This review summarizes neurotoxicity, cardiovascular toxicity, hepatotoxicity, toxicity in other organs, and biomonitoring of prenatal METH exposure, as well as the possible emergence of sensitization associated with METH. We proposed the importance of gut microbiota in studying prenatal METH exposure. There is rising evidence of the adverse effects of METH exposure during pregnancy, which are of significant concern.

Indexed as

adverse effectsmethamphetamineoffspringprenatal exposurepsychostimulant

Identifiers

PMID34335277
PMCPMC8317262
OpenAlexW3180803250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.